Relationship between serum ferritin levels and sarcopenia in Korean females aged 60 years and older using the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008-2009.
Relationship between serum ferritin levels and sarcopenia in Korean females aged 60 years and older using the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008-2009.
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DOI：
10.1371/journal.pone.0090105
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kim SH
中科院分区：
文献类型：
--
作者：
Kim TH;Hwang HJ;Kim SH
有人认为血清铁蛋白升高与多种代谢紊乱有关。然而，尽管肌肉减少症与代谢紊乱之间存在密切关系，但尚未有研究评估血清铁蛋白与肌肉减少症之间的关联。我们研究了血清铁蛋白是否与韩国老年人的肌肉减少症相关。我们根据第四次韩国国家健康和营养检查调查第二年和第三年（2008-9）获得的数据进行了一项横断面研究。总共有 952 名 60 岁及以上的男性（平均年龄 69.0 岁）和 1,380 名女性（平均年龄 69.3 岁）使用双能 X 射线吸收测定法完成了身体成分研究。测量血清铁蛋白水平。肌肉减少症的定义是四肢骨骼质量占体重的百分比低于年轻人特定性别平均值的两个标准差。女性血清铁蛋白水平低于男性。患有肌少症的女性比没有肌少症的女性血清铁蛋白水平更高（男性：无肌少症为 115.7 ng/mL，患有肌少症为 134.4 ng/mL，女性：无肌少症为 70.7 ng/mL，患有肌少症为 85.4 ng/mL）。随着血清铁蛋白三分位数的增加，肌肉减少症的患病率也随之增加。然而，统计显着性仅在老年女性中出现（第一三分位数 6.3%，第二三分位数 8.0%，第三三分位数 12.0%；p = 0.008）。在未经调整的情况下，与血清铁蛋白水平最低三分位的参与者相比，最高三分位的参与者的女性肌少症的优势比为 2.02（95% 置信区间 = 1.26–3.23）。调整已知危险因素后，女性肌少症的 OR 为 1.74 (95% CI = 1.02–2.97)。男性肌肉减少症与血清铁蛋白三分位数之间没有统计学上的显着关联。在韩国老年人的代表性样本中，血清铁蛋白水平升高与女性肌少症患病率增加有关，但与男性无关。
It has been suggested that elevated serum ferritin is associated with several metabolic disorders. However, there is no reported study assessing any association between serum ferritin and sarcopenia despite the close relationship between sarcopenia and metabolic disorders. We investigated whether serum ferritin was associated with sarcopenia in older Koreans. We conducted a cross-sectional study based on data acquired in the second and third years (2008–9) of the fourth Korean National Health and Nutrition Examination Survey. In total, 952 men (mean age 69.0 years) and 1,380 women (mean age 69.3 years) aged 60 years and older completed a body composition study using dual energy X-ray absorptiometry. Serum ferritin levels were measured. Sarcopenia was defined as an appendicular skeletal mass as a percentage of body weight that was less than two standard deviations below the gender-specific mean for young adults. Serum ferritin levels were lower in women than in men. Women with sarcopenia showed a higher level of serum ferritin than women without sarcopenia (men: without sarcopenia 115.7 ng/mL and with sarcopenia 134.4 ng/mL vs. women: without sarcopenia 70.7 ng/mL and with sarcopenia 85.4 ng/mL). The prevalence of sarcopenia increased as the tertile of serum ferritin increased. However, statistical significance was only seen in elderly women (1st tertile 6.3%, 2nd tertile 8.0%, 3rd tertile 12.0%; p = 0.008). Without adjustment, compared with those in the lowest tertile of serum ferritin level, participants in the highest tertile had an odds ratio of 2.02 (95% confidence interval = 1.26–3.23) for sarcopenia in women. After adjusting for known risk factors, the OR for sarcopenia was 1.74 (95% CI = 1.02–2.97) in women. There was no statistically significant association between sarcopenia and serum ferritin tertiles in men. Elevated serum ferritin levels were associated with an increased prevalence of sarcopenia in women but not in men from a representative sample of elderly Koreans.
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影响因子：
7.1
作者：
GAVIN, MW;MCCARTHY, DM;GARRY, PJ
通讯作者：
GARRY, PJ
影响因子：
3.4
作者：
Altun, Mikael;Edstrom, Erik;Ulfhake, Brun
通讯作者：
Ulfhake, Brun
DOI：
10.1093/gerona/glr022
发表时间：
2012-01-01
影响因子：
5.1
作者：
Kalyani, Rita R.;Metter, E. Jeffrey;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
16.2
作者：
Jehn, M;Clark, JM;Guallar, E
通讯作者：
Guallar, E
DOI：
10.1080/07315724.2000.10718925
发表时间：
2000-04-01
影响因子：
3.5
作者：
Garry, PJ;Hunt, WC;Baumgartner, RN
通讯作者：
Baumgartner, RN