A clinicopathologic study of paragangliomas of the urinary bladder: can the clinical behavior of the tumor be predicted?
A clinicopathologic study of paragangliomas of the urinary bladder: can the clinical behavior of the tumor be predicted?
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膀胱副神经节瘤的临床病理学研究：可以预测肿瘤的临床行为吗？
DOI：
10.14670/hh-11-751
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Guo Y;Yan Q;Wang L;Wang Z
血管浸润（LVI）是阴茎癌转移性淋巴结疾病的独立预测因子，也是指导临床治疗的因素之一。回顾性评估了46例阴茎切除术后浸润性阴茎癌（43例鳞状细胞癌和3例非鳞状细胞癌）中是否存在LVI（使用和不使用内皮细胞免疫组织化学（IHC）标记物ERG和CD 31）。确定了原始报告、病理学审查和使用IHC之间LVI检测的一致性，并确定了组织学缺陷。对于阴茎鳞状细胞癌，在原始报告中，27.9%的肿瘤诊断为LVI，16.3%在病理学审查时诊断为LVI，16.3%使用ERG和CD31。与IHC相比，原始报告中LVI鉴定的一致性为74.4%，而与IHC相比，审查的一致性为95.3%。使用IHC数据作为参考，假阳性LVI诊断在原始报告中比假阴性更常见。LVI的组织学模拟物包括阴茎海绵体或海绵体血管系统的参与，血清粘蛋白定植和肿瘤侵袭的巢状模式被确定。我们证明了阴茎癌中的LVI被过度诊断或诊断不足并不罕见。对于LVI在组织学上难以辨别的阴茎切除术病例，建议使用内皮IHC标记物，如ERG或CD31，或额外的病理学咨询。
Lymphovascular invasion (LVI) is an independent predictor of metastatic lymph node disease in penile carcinoma and is one factor used to guide clinical management. The presence of LVI with and without the use of the endothelial immunohistochemical (IHC) markers, ERG and CD31, was retrospectively assessed in 46 penectomy cases containing invasive penile carcinoma (43 squamous cell carcinoma and 3 non-squamous cell carcinoma). Concordance for the detection of LVI between the original report, upon pathology review, and with the use of IHC was determined and histologic pitfalls were identified. For penile squamous cell carcinoma, LVI was diagnosed in 27.9% of tumors in the original reports, 16.3% upon pathology review, and in 16.3% with use of ERG and CD31. Concordance of LVI identification in the original report compared to IHC was 74.4% while concordance of review compared to IHC was 95.3%. Using IHC data as the reference, false positive LVI diagnoses were more common in the original report than false negatives. Histologic mimickers of LVI including involvement of the penile corpora cavernosum or spongiosum vasculature, seromucinous colonization, and a nested pattern of tumor invasion were identified. We demonstrated that it was not uncommon for LVI in penile carcinoma to be overdiagnosed or underdiagnosed. The use of endothelial IHC markers, such as ERG or CD31, or additional pathology consultation is recommended for penectomy cases in which LVI is difficult to histologically discern.
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影响因子：
4.6
作者：
L. Pang;K. Tsao
通讯作者：
L. Pang;K. Tsao
影响因子：
3.9
作者：
A. Tischler;R. Krijger
通讯作者：
A. Tischler;R. Krijger
影响因子：
3.9
作者：
Kimura, Noriko;Takayanagi, Ryoichi;Naruse, Mitsuhide
通讯作者：
Naruse, Mitsuhide
DOI：
10.17511/jopm.2020.i04.11
发表时间：
2020-04
期刊：
Tropical Journal of Pathology and Microbiology
影响因子：
--
作者：
S. Fatima;Omaia Mahdy;S. W. Siddiqui
通讯作者：
S. Fatima;Omaia Mahdy;S. W. Siddiqui
影响因子：
5.6
作者：
Thompson, LDR
通讯作者：
Thompson, LDR