The Escherichia coli serS gene promoter region overlaps with the rarA gene.

The Escherichia coli serS gene promoter region overlaps with the rarA gene.
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DOI:
10.1371/journal.pone.0260282
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发表时间:
2022
期刊:
影响因子:
3.7
通讯作者:
Cox MM
Cox MM
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Jain K;Stanage TH;Wood EA;Cox MM

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编码大肠杆菌RARA蛋白的整个基因的缺失会导致生长缺陷和额外的缺陷,最初被归因于缺乏RARA功能。进一步的工作表明,大多数影响反映了RARA基因中影响下游基因SERS表达的序列的存在。SERS基因编码丝氨酰-tRNA合成酶。SERS表达的减少可以触发严苛的反应。影响SERS表达的序列位于RARA基因的最后15个核苷酸。
Deletion of the entire gene encoding the RarA protein of Escherichia coli results in a growth defect and additional deficiencies that were initially ascribed to a lack of RarA function. Further work revealed that most of the effects reflected the presence of sequences in the rarA gene that affect expression of the downstream gene, serS. The serS gene encodes the seryl aminoacyl-tRNA synthetase. Decreases in the expression of serS can trigger the stringent response. The sequences that affect serS expression are located in the last 15 nucleotides of the rarA gene.
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