Critical evaluation of the potential prognostic value of the pretreatment-derived neutrophil-lymphocyte ratio under consideration of C-reactive protein levels in clear cell renal cell carcinoma.
Critical evaluation of the potential prognostic value of the pretreatment-derived neutrophil-lymphocyte ratio under consideration of C-reactive protein levels in clear cell renal cell carcinoma.
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DOI：
10.1038/bjc.2016.393
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发表时间：
2017-01-03
影响因子：
8.8
通讯作者：
Pichler M
中科院分区：
文献类型：
--
作者：
Dalpiaz O;Luef T;Seles M;Stotz M;Stojakovic T;Pummer K;Zigeuner R;Hutterer GC;Pichler M
我们在一大群透明细胞肾细胞癌 (RCC) 患者中研究了治疗前衍生的中性粒细胞 - 淋巴细胞比率 (dNLR) 和原始 NLR 与常用炎症标志物 C 反应蛋白 (CRP) 的预后价值。对 2000 年至 2010 年间在同一三级学术中心进行手术的 587 例连续非转移性透明细胞肾细胞癌患者的临床病理学数据进行回顾性评估。根据接收者操作曲线分析得出的截止值对患者进行分类。使用 Kaplan-Meier 方法并应用多变量 Cox 比例模型评估总体 (OS)、癌症特异性 (CSS) 以及无转移生存 (MFS)。 Spearman 等级相关系数测试了 dNLR 与全身炎症反应的其他标志物之间的关联。治疗前NLR与dNLR之间的显着相关性较强（ρ=0.84），而dNLR与CRP之间的相关性较弱（ρ=0.18）。在多变量分析中，dNLR 实现了 CSS (P=0.037) 和 MFS (P=0.041) 的独立预测因子，而 CRP 被证实分别是 OS (P=0.010)、CSS (P=0.039) 和 MFS (P=0.005) 的独立预测因子。当 CRP 纳入多变量模型时，NLR 未能达到 OS、CSS 和 MFS 的独立预测状态。在研究队列中，治疗前 CRP 水平升高 (⩾10.0) 和 dNLR 升高 (>2) 是 CSS 和 MFS 的稳健独立预测因子。我们的数据表明 CRP 可能优于 NLR 和 dNLR。
We investigated the prognostic value of the pretreatment-derived neutrophil–lymphocyte ratio (dNLR) and original NLR in relation to the commonly used inflammation marker C-reactive protein (CRP) in a large cohort of patients with clear cell renal cell carcinoma (RCC). Clinicopathological data from 587 consecutive non-metastatic clear cell RCC patients, operated between 2000 and 2010 at a single tertiary academic center, were evaluated retrospectively. Patients were categorised according to a cutoff value derived from receiver operating curve analysis. Overall (OS), cancer-specific (CSS) as well as metastasis-free survival (MFS) were assessed using the Kaplan–Meier method and multivariate Cox proportional models were applied. Spearman's rank correlation coefficient tested the association between dNLR and other markers of the systemic inflammatory response. The significant correlation between pretreatment NLR and dNLR was strong (ρ=0.84), whereas between dNLR and CRP it was weak (ρ=0.18). In multivariate analyses, dNLR achieved independent predictor status regarding CSS (P=0.037) and MFS (P=0.041), whereas CRP was confirmed as independent predictor of OS (P=0.010), CSS (P=0.039) and MFS (P=0.005), respectively. The NLR failed to reach independent predictor status regarding OS, CSS and MFS when CRP was included into the multivariate model. In the cohort studied, an elevated (⩾10.0) pretreatment CRP level and elevated dNLR (>2) were robust independent predictors of CSS and MFS. Our data suggest that CRP might be superior to both NLR and dNLR.
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影响因子：
8.8
作者：
Dalpiaz, O.;Pichler, M.;Mannweiler, S.;Hernandez, J. M. Martin;Stojakovic, T.;Pummer, K.;Zigeuner, R.;Hutterer, G. C.
通讯作者：
Hutterer, G. C.
影响因子：
4.5
作者：
Dalpiaz, Orietta;Ehrlich, Georg C.;Hutterer, Georg C.
通讯作者：
Hutterer, Georg C.
影响因子：
2.8
作者：
Ding, Pei-Rong;An, Xin;Pan, Zhi-Zhong
通讯作者：
Pan, Zhi-Zhong
影响因子：
3.4
作者：
Pichler, Martin;Hutterer, Georg C.;Zigeuner, Richard
通讯作者：
Zigeuner, Richard
影响因子：
10.6
作者：
Riemann, Dagmar;Hase, Sabine;Seliger, Barbara
通讯作者：
Seliger, Barbara