PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization.
PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization.
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DOI：
10.1016/j.nicl.2022.103146
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发表时间：
2022
影响因子：
4.2
通讯作者：
Esterman, Michael
中科院分区：
文献类型：
--
作者：
Evans, Travis C.;Alonso, Marina Rodriguez;Jagger-Rickels, Audreyana;Rothlein, David;Zuberer, Agnieszka;Bernstein, John;Fortier, Catherine B.;Fonda, Jennifer R.;Villalon, Audri;Jorge, Ricardo;Milberg, William;McGlinchey, Regina;DeGutis, Joseph;Esterman, Michael
重复与创伤后应激障碍相关的联系，降低维持注意力的能力。创伤后应激障碍症状与更冲动的反应策略无关。创伤后应激障碍症状与丹大脑行为同步性降低有关。DAN同步性降低与持续注意力能力降低相关。创伤后应激障碍症状可能会扰乱注意控制回路的主动参与。创伤后应激障碍(PTSD)的症状与调节失调的持续注意力有关，这会产生功能障碍。在持续性注意范式上的表现，如持续性任务，既受维持注意能力的影响，也受反应策略的影响。然而，以前的研究并没有将创伤后应激障碍与持续的注意能力和策略联系起来，这限制了对与创伤后应激障碍相关的注意障碍的神经回路的表征。因此，我们在创伤暴露的退伍军人中表征和复制了创伤后应激障碍与持续注意能力和反应策略的关联，从而指导表征与创伤后应激障碍相关的神经回路功能的差异。在研究1中，创伤后应激障碍症状选择性地与持续注意力能力下降有关，但与更多的冲动反应策略无关。在研究2中，我们利用任务和静息状态的功能磁共振成像来表征与创伤后应激障碍相关的持续注意能力差异背后的神经回路。创伤后应激障碍症状和持续注意能力与背部注意网络(DAN)同步性降低和内源性注意波动呈趋同关系。事后的时间进程分析表明，创伤后应激障碍症状最准确的特征是与内源性注意波动的DAN同步延迟，而不是整体减少。综上所述，这些发现表明，创伤后应激障碍症状可能通过扰乱注意控制回路的主动参与来选择性地损害持续的注意力能力。
Replicated PTSD-related associations with reduced ability to sustain attention. PTSD symptoms were not associated with more impulsive response strategies. PTSD symptoms associated with reduced brain-behavior synchronization of DAN. Reduced DAN synchronization associated with reduced sustained attention ability. PTSD symptoms may disrupt proactive engagement of attentional control circuitry. Posttraumatic Stress Disorder (PTSD) symptomatology is associated with dysregulated sustained attention, which produces functional impairments. Performance on sustained attention paradigms such as continuous performance tasks are influenced by both the ability to sustain attention and response strategy. However, previous studies have not dissociated PTSD-related associations with sustained attention ability and strategy, which limits characterization of neural circuitry underlying PTSD-related attentional impairments. Therefore, we characterized and replicated PTSD-related associations with sustained attention ability and response strategy in trauma-exposed Veterans, which guided characterization of PTSD-related differences in neural circuit function. In Study 1, PTSD symptoms were selectively associated with reduced sustained attention ability, but not more impulsive response strategies. In Study 2, we utilized task and resting-state fMRI to characterize neural circuitry underlying PTSD-related differences in sustained attention ability. Both PTSD symptomatology and sustained attention ability exhibited converging associations with reduced dorsal attention network (DAN) synchronization to endogeneous attentional fluctuations. Post-hoc time course analyses demonstrated that PTSD symptoms were most accurately characterized by delayed, rather than globally reduced, DAN synchronization to endogenous attentional fluctuations. Together, these findings suggest that PTSD symptomatology may selectively impair sustained attention ability by disrupting proactive engagement of attentional control circuitry.
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影响因子：
8.2
作者：
Fortenbaugh FC;DeGutis J;Germine L;Wilmer JB;Grosso M;Russo K;Esterman M
通讯作者：
Esterman M
影响因子：
0.5
作者：
Campbell, Thomas A.;Nelson, Lonnie A.;McCormick, Cortney L.
通讯作者：
McCormick, Cortney L.
影响因子：
3.8
作者：
Danielmeier C;Ullsperger M
通讯作者：
Ullsperger M
影响因子：
4.7
作者：
Aupperle RL;Melrose AJ;Stein MB;Paulus MP
通讯作者：
Paulus MP
影响因子：
5.7
作者：
Fortenbaugh FC;Rothlein D;McGlinchey R;DeGutis J;Esterman M
通讯作者：
Esterman M