Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1).
Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1).
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DOI：
10.1111/j.1750-2659.2009.00096.x
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发表时间：
2009-09
影响因子：
4.4
通讯作者：
Webby RJ
中科院分区：
文献类型：
--
作者：
Brockwell-Staats C;Webster RG;Webby RJ
摘要2009年初在墨西哥人类中出现的新型H1N1流感病毒已被宣布为大流行毒株，并在全球范围内有效传播。 在这里，我们回顾了自1918年以来的猪流感感染，以及将不同的禽流感和人流感病毒基因引入北美和欧亚大陆的猪流感病毒。这些引入通常导致病毒对猪的适应性增加，偶尔传播给人类。影响人类的新型病毒来源于北美猪流感病毒，该病毒已从欧洲猪谱系获得两个基因片段[神经氨酸酶（NA）和基质（M）]。这种抑制剂似乎增加了人类的健康。新型H1N1流感病毒在人类中的毒力可能增加，并可能与对奥司他韦耐药的季节性H1N1流感病毒或高致病性H5N1流感病毒发生进一步的重配，这突出表明需要紧急制定大流行病规划。
Abstract The novel H1N1 influenza virus that emerged in humans in Mexico in early 2009 and transmitted efficiently in the human population with global spread has been declared a pandemic strain. Here we review influenza infections in swine since 1918 and the introduction of different avian and human influenza virus genes into swine influenza viruses of North America and Eurasia. These introductions often result in viruses of increased fitness for pigs that occasionally transmit to humans. The novel virus affecting humans is derived from a North American swine influenza virus that has acquired two gene segments [Neuraminidase (NA) and Matrix (M)] from the European swine lineages. This reassortant appears to have increased fitness in humans. The potential for increased virulence in humans and of further reassortment between the novel H1N1 influenza virus and oseltamivir resistant seasonal H1N1 or with highly pathogenic H5N1 influenza stresses the need for urgent pandemic planning.
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