Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder.
Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.biopsych.2008.10.015
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发表时间：
2009-04-01
影响因子：
10.6
通讯作者：
Zhou, Xiaohong Joe
中科院分区：
文献类型：
--
作者：
Pavuluri, Mani N.;Yang, Shuohui;Kamineni, Kiran;Passarotti, Alessandra M.;Srinivasan, Girish;Harral, Erin M.;Sweeney, John A.;Zhou, Xiaohong Joe
关键词：
目的研究儿童双相情感障碍（PBD）和注意缺陷多动障碍（ADHD）的白色纤维束的显微结构。在3特斯拉下对年龄和智商匹配的儿童和青少年PBD（n=13）、ADHD（n=13）和健康对照（HC）（n=15）进行了弥散张量成像（DTI）研究。对前放射冠（ACR）、内囊前肢（ALIC）、内囊上级区（SRI）、内囊后肢（PLIC）、上纵束（SLF）、下纵束（ILF）、上级纵束（LLF）、下扣带（CG）;压部（SP）。相对于HC，在PBD和ADHD的ACR中观察到显著较低的FA。此外，在ALIC和SRI中，ADHD的FA和r-FCI值显著低于PBD和HC。此外，在ACR、ALIC、PLIC、SRI、CG、ILF和SLF中，ADHD的ADC显著大于PBD和HC。ACR中FA的减少意味着PBD和ADHD中该前额束的纤维密度受损或髓鞘形成减少。这些异常以及纤维连贯性的降低延伸到多动症患者的皮质球束。ADHD患者多个白色束的ADC增加表明ADHD患者广泛的细胞异常，相对于PBD，ADHD患者的扩散限制较少。
To investigate microstructure of white matter fiber tracts in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). A diffusion tensor imaging (DTI) study was conducted at 3 Tesla on age and IQ-matched children and adolescents with PBD (n=13), ADHD (n=13), and healthy controls (HC) (n=15). Three DTI parameters, fractional anisotropy (FA), apparent diffusion coefficient (ADC), and regional fiber coherence index (r-FCI), were examined in eight fiber tracts: Anterior corona radiata (ACR); anterior limb of the internal capsule (ALIC); superior region of the internal capsule (SRI); posterior limb of the internal capsule (PLIC); superior longitudinal fasciculus (SLF); inferior longitudinal fasciculus (ILF); cingulum (CG); splenium (SP). Significantly lower FA was observed in ACR in both PBD and ADHD relative to HC. In addition, FA and r-FCI values were significantly lower in ADHD relative to PBD and HC in both the ALIC and the SRI. Further, ADC was significantly greater in ADHD relative to both the PBD and HC in ACR, ALIC, PLIC, SRI, CG, ILF, and SLF. Decreased FA in ACR implies an impaired fiber density or reduced myelination in both PBD and ADHD in this prefrontal tract. These abnormalities, together with the reduced fiber coherence, extended to cortico-bulbar tracts in ADHD. Increased ADC across multiple white matter tracts in ADHD indicates extensive cellular abnormalities with less diffusion restriction in ADHD relative to PBD.
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影响因子：
10.6
作者：
Doyle, AE;Wilens, TE;Biederman, J
通讯作者：
Biederman, J
影响因子：
10.6
作者：
Biederman, J;Mick, E;Wozniak, J
通讯作者：
Wozniak, J
影响因子：
17.7
作者：
Leibenluft, Ellen;Rich, Brendan A.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
10.1097/00004583-200403000-00016
发表时间：
2004-03-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H
影响因子：
17.7
作者：
Blumberg, HP;Martin, A;Peterson, BS
通讯作者：
Peterson, BS