Atlas-guided volumetric diffuse optical tomography enhanced by generalized linear model analysis to image risk decision-making responses in young adults.
Atlas-guided volumetric diffuse optical tomography enhanced by generalized linear model analysis to image risk decision-making responses in young adults.
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DOI：
10.1002/hbm.22459
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发表时间：
2014-08
影响因子：
4.8
通讯作者：
Liu, Hanli
中科院分区：
文献类型：
--
作者：
Lin, Zi-Jing;Li, Lin;Cazzell, Mary;Liu, Hanli
漫射光学断层扫描（DOT）是功能性近红外光谱的一种变体，具有映射或重建大脑活动引起的三维血流动力学变化的能力。由于激活周期的选择相对主观，常用的DOT图像分析定义脑激活的方法存在局限性。基于一般线性模型（GLM）的分析可以克服这一限制。在这项研究中，我们将地图集引导的3D DOT图像重建与基于GLM的分析（即，基于体素的GLM分析）结合起来，研究与风险决策过程相关的大脑活动。风险决策是一个重要的认知过程，因此是神经科学领域的一个重要课题。气球模拟风险任务（BART）是一个有效的实验模型，通常用于评估人类在面临风险时采取的风险行动和倾向。我们使用BART范式和封闭设计来研究37名人类参与者（22名男性和15名女性）在决策过程中前额叶和额叶皮质区的大脑激活情况。在人脑图谱模板和深度补偿算法相结合形成图谱引导DOT图像后，进行体素级GLM分析。在这项工作中，我们希望证明使用体素智能GLM分析与DOT来成像和研究响应风险决策的认知功能的卓越性。结果表明，在主动选择模式下，背外侧前额叶皮层（DLPFC）的血流动力学发生了显著变化，并且在性别之间有不同的激活模式；这些发现与功能性磁共振成像（fMRI）和近红外光谱（fNIRS）研究的已发表文献相吻合。中国生物医学工程学报（英文版），2014。©2014作者。由Wiley期刊公司出版的人类大脑图谱。
Diffuse optical tomography (DOT) is a variant of functional near infrared spectroscopy and has the capability of mapping or reconstructing three dimensional (3D) hemodynamic changes due to brain activity. Common methods used in DOT image analysis to define brain activation have limitations because the selection of activation period is relatively subjective. General linear model (GLM)‐based analysis can overcome this limitation. In this study, we combine the atlas‐guided 3D DOT image reconstruction with GLM‐based analysis (i.e., voxel‐wise GLM analysis) to investigate the brain activity that is associated with risk decision‐making processes. Risk decision‐making is an important cognitive process and thus is an essential topic in the field of neuroscience. The Balloon Analog Risk Task (BART) is a valid experimental model and has been commonly used to assess human risk‐taking actions and tendencies while facing risks. We have used the BART paradigm with a blocked design to investigate brain activations in the prefrontal and frontal cortical areas during decision‐making from 37 human participants (22 males and 15 females). Voxel‐wise GLM analysis was performed after a human brain atlas template and a depth compensation algorithm were combined to form atlas‐guided DOT images. In this work, we wish to demonstrate the excellence of using voxel‐wise GLM analysis with DOT to image and study cognitive functions in response to risk decision‐making. Results have shown significant hemodynamic changes in the dorsal lateral prefrontal cortex (DLPFC) during the active‐choice mode and a different activation pattern between genders; these findings correlate well with published literature in functional magnetic resonance imaging (fMRI) and fNIRS studies. Hum Brain Mapp 35:4249–4266, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
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影响因子：
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作者：
Dehghani, Hamid;Eames, Matthew E.;Yalavarthy, Phaneendra K.;Davis, Scott C.;Srinivasan, Subhadra;Carpenter, Colin M.;Pogue, Brian W.;Paulsen, Keith D.
通讯作者：
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