Three-dimensional assessment of brain arterial compliance: Technical development, comparison with aortic pulse wave velocity, and age effect.
Three-dimensional assessment of brain arterial compliance: Technical development, comparison with aortic pulse wave velocity, and age effect.
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DOI：
10.1002/mrm.28835
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发表时间：
2021-10
影响因子：
3.3
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Li Y;Lim C;Schär M;Jiang D;Qiao Y;Pillai JJ;Lu H
脑血管顺应性（VC）的测量能力在血管疾病的评价中是重要的。此外，脑中动脉壁搏动的量化可能有助于理解最近发现的胶质淋巴系统的驱动力。我们的目标是开发一种MRI技术来测量颅内主要血管的VC和动脉壁搏动。共17名健康受试者在3特斯拉MRI系统上进行了研究。该技术被称为VaCom-PCASL，使用伪连续动脉自旋标记（PCASL）来获得纯血管信号，采用3D径向采集，并应用黄金角径向稀疏并行（GRASP）算法进行图像重建。k空间数据被回顾性地分类到不同的心脏时相。GRASP算法允许同时重建五维（三个空间维度、一个对照/标签维度和一个心脏相位维度）数据。该技术在重建参数和标记时间方面进行了优化。将颅内VC与相位对比MRI测量的主动脉脉搏波速度（PWV）进行比较。研究了VC的年龄差异。VaCom-PCASL使用10个心脏相位和GRASP稀疏性约束λlabel/control=0.05和λcardiac=0.05，提供了最高的对比噪声比。发现800 ms的标记持续时间产生的信号与较长持续时间的信号相当（p>0.2），而400 ms产生显著的高估（p<0.005）。颅内VC和主动脉PWV之间存在显著相关性（r=-0.73，p=0.038，N=8）。老年组血管顺应性低于青年组。VaCom-PCASL MRI是一种有前途的无创评估动脉僵硬度和搏动性的方法。
The ability to measure cerebral vascular compliance (VC) is important in the evaluation of vascular diseases. Additionally, quantification of arterial wall pulsation in the brain may be useful for understanding the driving force of the recently discovered glymphatic system. Our goal is to develop an MRI technique to measure VC and arterial wall pulsation in major intracranial vessels. A total of 17 healthy subjects were studied on a 3 Tesla MRI system. The technique, dubbed VaCom-PCASL, uses pseudo-continuous-arterial-spin-labeling (PCASL) to obtain pure blood vessel signal, employs a 3D radial acquisition, and applies a golden-angle-radial-sparse-parallel (GRASP) algorithm for image reconstruction. The k-space data were retrospectively sorted into different cardiac phases. The GRASP algorithm allows the reconstruction of five-dimensional (three spatial dimensions, one control/label dimension, and one cardiac-phase dimension) data simultaneously. The proposed technique was optimized in terms of reconstruction parameters and labeling duration. Intracranial VC was compared with aortic pulse-wave-velocity (PWV) measured with phase-contrast MRI. Age differences in VC were studied. VaCom-PCASL using 10 cardiac phases and GRASP sparsity constraints of λlabel/control=0.05 and λcardiac=0.05 provided the highest contrast-to-noise ratio. A labeling duration of 800 ms was found to yield signals comparable to those of longer duration (p>0.2), whereas 400 ms yielded significant over-estimation (p<0.005). A significant correlation was observed between intracranial VC and aortic PWV (r=−0.73, p=0.038, N=8). Vascular compliance in the older group was lower than that in the younger group. VaCom-PCASL MRI represents a promising approach for non-invasive assessment of arterial stiffness and pulsatility.
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影响因子：
3.3
作者：
Feng, Li;Grimm, Robert;Block, Kai Tobias;Chandarana, Hersh;Kim, Sungheon;Xu, Jian;Axel, Leon;Sodickson, Daniel K.;Otazo, Ricardo
通讯作者：
Otazo, Ricardo
影响因子：
37.8
作者：
Sutton-Tyrrell, K;Najjar, SS;Newman, A
通讯作者：
Newman, A
影响因子：
3.3
作者：
Coppo, Simone;Piccini, Davide;Stuber, Matthias
通讯作者：
Stuber, Matthias
影响因子：
2.8
作者：
Groenink, M;de Roos, A;van der Wall, EE
通讯作者：
van der Wall, EE
影响因子：
6.7
作者：
Chandarana H;Feng L;Block TK;Rosenkrantz AB;Lim RP;Babb JS;Sodickson DK;Otazo R
通讯作者：
Otazo R