Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin.
Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin.
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DOI：
10.1038/s41467-022-28308-6
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发表时间：
2022-02-03
影响因子：
16.6
通讯作者：
Lockley SW
中科院分区：
文献类型：
--
作者：
Kent BA;Rahman SA;St Hilaire MA;Grant LK;Rüger M;Czeisler CA;Lockley SW
虽然研究表明，光照和进食模式可以重置各种代谢物的昼夜节律，但这些变化是否遵循可预测的模式尚不清楚。我们描述了第一阶段的响应曲线（PRC）的脂质和肝蛋白质的光和食物刺激相结合。在暴露于6.5小时蓝光暴露和标准膳食计划之前和之后，通过恒定的常规评估血浆节律的时间，个体之间的系统变化约为20°。我们发现，节奏的变化，根据一个PRC，一般更大的变化，脂质和肝蛋白比褪黑激素。PRC时间相对于刺激而变化，白蛋白和甘油三酯PRC在与褪黑激素相似的时间达到峰值，而胆固醇和高密度脂蛋白PRC偏移约12小时。这些数据对于治疗那些每天吃饭并全天候暴露在光线下的轮班工作者的昼夜节律失调具有重要意义。昼夜节律的一个关键特性是它们可以响应于环境时间线索而重置;这种响应由相位响应曲线（PRC）描述。在这里，作者描述了PRCs用于重置脂质和肝蛋白的昼夜节律，以响应光和食物暴露的组合。
While studies suggest that light and feeding patterns can reset circadian rhythms in various metabolites, whether these shifts follow a predictable pattern is unknown. We describe the first phase response curves (PRC) for lipids and hepatic proteins in response to combined light and food stimuli. The timing of plasma rhythms was assessed by constant routine before and after exposure to a combined 6.5-hour blue light exposure and standard meal schedule, which was systematically varied by ~20° between individuals. We find that the rhythms shift according to a PRC, with generally greater shifts for lipids and liver proteins than for melatonin. PRC timing varies relative to the stimulus, with albumin and triglyceride PRCs peaking at a time similar to melatonin whereas the cholesterol and high-density lipoprotein PRCs are offset by ~12 h. These data have important implications for treating circadian misalignment in shiftworkers who consume meals and are exposed to light around the clock. A key property of circadian rhythms is that they can be reset in response to environmental time cues; this response is described by a Phase Response Curve (PRC). Here the authors describe PRCs for resetting circadian rhythms in lipids and hepatic proteins in response to combined light and food exposure.
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影响因子：
3.4
作者：
Fisk AS;Tam SKE;Brown LA;Vyazovskiy VV;Bannerman DM;Peirson SN
通讯作者：
Peirson SN
影响因子：
2.8
作者：
Gu, Fangyi;Klerman, Elizabeth B.;Caporaso, Neil E.
通讯作者：
Caporaso, Neil E.
DOI：
10.1152/ajpregu.00397.2003
发表时间：
2004-06-01
影响因子：
2.8
作者：
Barger, LK;Wright, KP;Czeisler, CA
通讯作者：
Czeisler, CA
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U
影响因子：
4.2
作者：
Gnocchi D;Pedrelli M;Hurt-Camejo E;Parini P
通讯作者：
Parini P