Fluid compartments influence elastography of the aging mouse brain.
Fluid compartments influence elastography of the aging mouse brain.
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DOI：
10.1088/1361-6560/acc922
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发表时间：
2023-04-17
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
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作者：
目标。脑弹性成像有可能揭示细微但临床上重要的结构和组成变化，作为年龄、疾病和损伤的功能。的方法。为了量化衰老对小鼠脑弹性成像的具体影响，并确定影响观察到变化的关键因素，我们对一组从年轻到老年的野生型健康小鼠进行了2000 Hz的光学相干断层扫描反射横波弹性成像。主要的结果。我们发现，随着年龄的增长，刚度增加的趋势很强，在这个样本组中，从2个月到30个月，横波速度增加了大约30%。此外，这似乎与全脑液体含量的减少密切相关，因此老年人的大脑含水量更少，更硬。应用流变学模型，通过对脑液结构的淋巴腔室变化的特定分配以及脑实质刚度的相关变化，捕获了强效应。的意义。弹性成像测量的短期和长期变化可能为脑内淋巴流体通道和实质成分的进行性和细尺度变化提供敏感的生物标志物。
Objective. Elastography of the brain has the potential to reveal subtle but clinically important changes in the structure and composition as a function of age, disease, and injury. Approach. In order to quantify the specific effects of aging on mouse brain elastography, and to determine the key factors influencing observed changes, we applied optical coherence tomography reverberant shear wave elastography at 2000 Hz to a group of wild-type healthy mice ranging from young to old age. Main results. We found a strong trend towards increasing stiffness with age, with an approximately 30% increase in shear wave speed from 2 months to 30 months within this sampled group. Furthermore, this appears to be strongly correlated with decreasing measures of whole brain fluid content, so older brains have less water and are stiffer. Rheological models are applied, and the strong effect is captured by specific assignment of changes to the glymphatic compartment of the brain fluid structures along with a correlated change in the parenchymal stiffness. Significance. Short-term and longer-term changes in elastography measures may provide a sensitive biomarker of progressive and fine-scale changes in the glymphatic fluid channels and parenchymal components of the brain.
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影响因子：
14.5
作者：
LEENDERS, KL;PERANI, D;JONES, T
通讯作者：
JONES, T
影响因子：
5.7
作者：
Murphy MC;Huston J 3rd;Ehman RL
通讯作者：
Ehman RL
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
通讯作者：
Starr JM
影响因子：
5.7
作者：
Hiscox LV;Schwarb H;McGarry MDJ;Johnson CL
通讯作者：
Johnson CL
影响因子：
4.8
作者：
通讯作者：
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