Magnetic resonance elastography of the ageing brain in normal and demented populations: A systematic review.
Magnetic resonance elastography of the ageing brain in normal and demented populations: A systematic review.
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DOI：
10.1002/hbm.25891
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发表时间：
2022-09
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
本系统综述的目的是评价磁共振弹性成像（MRE）识别正常和病理老化过程中脑机械特性显著变化的能力。在PubMed、Web of Science和Scopus中检索了使用MRE评估认知健康个体、有痴呆风险的个体或诊断为痴呆的患者的大脑机械特性的人体研究。研究特征、样本人口统计学、临床表征和主要MRE结局总结见表。共纳入了19项研究（9项老化，10项痴呆），包括700名参与者。主要的发现是大脑硬度随着年龄的增长沿着降低，年变化率在-0.008到-0.025千帕之间。此外，年龄对脑硬度的影响存在地区差异。关于痴呆患者，不同的痴呆亚型的僵硬度的差异模式。与认知健康的对照组相比，阿尔茨海默病和额颞叶痴呆表现出降低的脑硬度，并且在已知受疾病影响的区域中发现显著下降。在正常压力脑积水，结果并不一致的研究，并在路易体痴呆症没有显着差异，在脑stiffness被发现。总之，老化的特点是软化的脑组织，这一事件是更加明显的病理老化，如痴呆症。MRE技术可以作为一种明智的诊断工具，用于识别与正常衰老的偏差，并开发新的认知衰退/痴呆的大脑生物标志物，这将有助于促进更健康的认知衰老。最近，磁共振弹性成像（MRE）已成为一种定量评估组织硬度的非侵入性成像技术，并已应用于研究健康和病理条件下人脑的机械特性。本系统综述的主要目的是评价MRE识别正常衰老和痴呆患者脑机械特性显著变化的能力。现有的证据表明，衰老的特征是脑组织软化，这一事件在病理性衰老中更为明显，如痴呆症。MRE技术可以作为一种明智的诊断工具，用于识别与正常衰老的偏差，并开发新的认知衰退/痴呆的大脑生物标志物，这将有助于促进更健康的认知衰老。
The aim of this systematic review was to evaluate the ability of magnetic resonance elastography (MRE) to identify significant changes in brain mechanical properties during normal and pathological aging. PubMed, Web of Science and Scopus were searched for human studies using MRE to assess brain mechanical properties in cognitively healthy individuals, individuals at risk of dementia or patients diagnosed with dementia. Study characteristics, sample demographics, clinical characterization and main MRE outcomes were summarized in a table. A total of 19 studies (nine aging, 10 dementia), comprising 700 participants, were included. The main findings were decreased cerebral stiffness along aging, with rates of annual change ranging from −0.008 to −0.025 kPa per year. Also, there were regional differences in the age effect on brain stiffness. Concerning demented patients, differential patterns of stiffness were found for distinct dementia subtypes. Alzheimer's disease and frontotemporal dementia exhibited decreased brain stiffness in comparison to cognitively healthy controls and significant declines were found in regions known to be affected by the disease. In normal pressure hydrocephalus, the results were not consistent across studies, and in dementia with Lewy bodies no significant differences in brain stiffness were found. In conclusion, aging is characterized by the softening of brain tissue and this event is even more pronounced in pathological aging, such as dementia. MRE technique could be applied as a sensible diagnostic tool to identify deviations from normal aging and develop new brain biomarkers of cognitive decline/dementia that would help promote healthier cognitive aging. Recently, magnetic resonance elastography (MRE) has emerged as a noninvasive imaging technique that quantitatively evaluates tissue stiffness and it has been applied to study the mechanical properties of the human brain in healthy and pathological conditions. The main goal of this systematic review was to evaluate the ability of MRE to identify significant changes in brain mechanical properties during normal aging and in patients with dementia. The available evidence revealed that aging is characterized by the softening of brain tissue and this event is even more pronounced in pathological aging, such as dementia. MRE technique could be applied as a sensible diagnostic tool to identify deviations from normal aging and develop new brain biomarkers of cognitive decline/dementia that would help promote healthier cognitive aging.
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影响因子：
3.5
作者：
Daugherty AM;Bender AR;Raz N;Ofen N
通讯作者：
Ofen N
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
通讯作者：
Starr JM
影响因子：
5.7
作者：
Hiscox LV;Schwarb H;McGarry MDJ;Johnson CL
通讯作者：
Johnson CL
影响因子：
3.7
作者：
Klein C;Hain EG;Braun J;Riek K;Mueller S;Steiner B;Sack I
通讯作者：
Sack I
影响因子：
5
作者：
ElSheikh, Mona;Arani, Arvin;Huston, John, III
通讯作者：
Huston, John, III