Association of obesity status and metabolic syndrome with site-specific cancers: a population-based cohort study.
Association of obesity status and metabolic syndrome with site-specific cancers: a population-based cohort study.
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肥胖状况和代谢综合征与特定部位癌症的关联：基于人群的队列研究
DOI：
10.1038/s41416-020-1012-6
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发表时间：
2020-10
影响因子：
8.8
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Cao Z;Zheng X;Yang H;Li S;Xu F;Yang X;Wang Y
背景肥胖和代谢综合征（MetS）呈簇状出现，且均与癌症风险增加相关。然而，它仍然是未知的肥胖状态是否有或没有代谢综合征增加的风险，特定部位cancer.MethodsWe使用的数据来自390，575个人（37-73岁）从英国生物银行谁参加了从2006年至2016年的中位数为7.8年的后续行动。肥胖定义为BMI ≥ 30 kg/m2，MetS定义为成人治疗小组-III（ATP-III）标准。考克斯比例风险模型被用来调查的BMI和代谢综合征与22 cancers.ResultsMetabolically健康肥胖（MHO）和代谢不健康肥胖（MUO）表型分别占6.7%和17.9%的总分析样本和27.1%和72.9%的肥胖亚群，分别。肥胖与22种癌症中的10种的高风险独立相关。按代谢状态分层，MUO表型始终与10种肥胖相关癌症相关。相比之下，MHO表型仅与五种癌症的风险增加相关：子宫内膜癌，食道癌，肾癌，胰腺癌和绝经后乳腺癌。ConclusionEven在代谢健康的个体中，肥胖与五种癌症的风险增加相关，而我们没有发现这些个体与其他几种肥胖相关癌症的风险增加相关。
BackgroundObesity and metabolic syndrome (MetS) appear in clusters and are both associated with an increased risk of cancer. However, it remains unknown whether obesity status with or without MetS increases the risk of site-specific cancers.MethodsWe used data derived from 390,575 individuals (37–73 years old) from the UK Biobank who were enrolled from 2006–2016 with a median of 7.8 years of follow-up. Obesity was defined by BMI ≥ 30 kg/m2and MetS was defined by the criteria of the Adult Treatment Panel-III (ATP-III). Cox proportional hazards models were used to investigate the associations of BMI and MetS with 22 cancers.ResultsMetabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) phenotypes represented 6.7% and 17.9% of the total analytic samples and 27.1% and 72.9% of the included subpopulation with obesity, respectively. Obesity was independently associated with higher risks of 10 of 22 cancers. Stratified by metabolic status, the MUO phenotype was consistently associated with 10 obesity-related cancers. In contrast, the MHO phenotype was only associated with increased risks of five cancers: endometrium, oesophagus, kidney, pancreas and postmenopausal breast cancers.ConclusionEven in metabolically healthy individuals, obesity was associated with increased risks of five cancers, whereas we did not find that these individuals were associated with increased risks of several other obesity-related cancers.
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代谢健康降低了弗雷明汉研究成年人中与肥胖相关癌症的风险。
DOI：
10.1158/1055-9965.epi-14-0240
发表时间：
2014-10
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Moore LL;Chadid S;Singer MR;Kreger BE;Denis GV
通讯作者：
Denis GV
影响因子：
39.3
作者：
Lassale C;Tzoulaki I;Moons KGM;Sweeting M;Boer J;Johnson L;Huerta JM;Agnoli C;Freisling H;Weiderpass E;Wennberg P;van der A DL;Arriola L;Benetou V;Boeing H;Bonnet F;Colorado-Yohar SM;Engström G;Eriksen AK;Ferrari P;Grioni S;Johansson M;Kaaks R;Katsoulis M;Katzke V;Key TJ;Matullo G;Melander O;Molina-Portillo E;Moreno-Iribas C;Norberg M;Overvad K;Panico S;Quirós JR;Saieva C;Skeie G;Steffen A;Stepien M;Tjønneland A;Trichopoulou A;Tumino R;van der Schouw YT;Verschuren WMM;Langenberg C;Di Angelantonio E;Riboli E;Wareham NJ;Danesh J;Butterworth AS
通讯作者：
Butterworth AS
影响因子：
5.6
作者：
Janssen, I;Katzmarzyk, PT;Ross, R
通讯作者：
Ross, R
影响因子：
6.4
作者：
Guo W;Key TJ;Reeves GK
通讯作者：
Reeves GK
影响因子：
6.9
作者：
Choromanska, Barbara;Mysliwiec, Piotr;Miklosz, Agnieszka
通讯作者：
Miklosz, Agnieszka