Alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in humans.
Alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in humans.
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DOI：
10.3389/fnhum.2015.00116
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发表时间：
2015
影响因子：
2.9
通讯作者：
Salas R
中科院分区：
文献类型：
--
作者：
Viswanath H;Velasquez KM;Thompson-Lake DG;Savjani R;Carter AQ;Eagleman D;Baldwin PR;De La Garza R 2nd;Salas R
异常的半球间功能连接与几种神经和精神疾病相关，包括抑郁症、强迫症、精神分裂症和中风。异常的大脑半球间功能连接也与大麻和可卡因的滥用有关。在本报告中，我们评估了烟草滥用（即，吸烟）与改变的半球间连接有关。为此，我们研究了静息状态功能连接（RSFC），使用磁共振成像（MRI）在短期的烟草剥夺和吸烟，如通常的吸烟者，和非吸烟者的控制。此外，我们比较了相同受试者的弥散张量成像（DTI），以研究白色物质的差异。数据显示，与对照组相比，吸烟者的大脑半球间功能连接显著增加。这种差异在额叶区域更大，并且与每天吸烟的平均数量呈正相关。此外，我们还发现胼胝体的DTI流线数量与每天吸烟的数量呈负相关。综上所述，我们的研究结果表明，目前吸烟者的大脑半球间的功能和解剖连接的变化。
Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In the current report, we evaluated whether tobacco abuse (i.e., cigarette smoking) is associated with altered interhemispheric connectivity. To that end, we examined resting state functional connectivity (RSFC) using magnetic resonance imaging (MRI) in short term tobacco deprived and smoking as usual tobacco smokers, and in non-smoker controls. Additionally, we compared diffusion tensor imaging (DTI) in the same subjects to study differences in white matter. The data reveal a significant increase in interhemispheric functional connectivity in sated tobacco smokers when compared to controls. This difference was larger in frontal regions, and was positively correlated with the average number of cigarettes smoked per day. In addition, we found a negative correlation between the number of DTI streamlines in the genual corpus callosum and the number of cigarettes smoked per day. Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette smokers.
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影响因子：
25.8
作者：
Lerman, Caryn;Gu, Hong;Loughead, James;Ruparel, Kosha;Yang, Yihong;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
慢性海洛因依赖导致的白质损伤：定量 DTI 研究
影响因子：
2.9
作者：
Li, Wei;Li, Qiang;Wang, Wei
通讯作者：
Wang, Wei
影响因子：
2.9
作者：
Hänggi J;Fövenyi L;Liem F;Meyer M;Jäncke L
通讯作者：
Jäncke L
影响因子：
5.3
作者：
Knoch, D;Gianotti, LRR;Brugger, P
通讯作者：
Brugger, P
影响因子：
2.8
作者：
Barr, Mera S.;Farzan, Faranak;Daskalakis, Zafiris J.
通讯作者：
Daskalakis, Zafiris J.