Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.
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DOI：
10.1038/s41551-021-00810-0
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发表时间：
2022-10
影响因子：
28.1
通讯作者：
中科院分区：
文献类型：
--
作者：
提供机械支撑和持续释放治疗剂的水凝胶已用于治疗肌腱损伤。然而，大多数水凝胶的坚韧不足，会突然释放药物，并且需要细胞浸润或渗透才能与周围组织整合。在这里，我们报告说，水凝胶作为一个高容量的药物仓库，并结合耗散坚韧的矩阵在一侧和壳聚糖粘合剂表面的另一侧支持肌腱滑动和强大的附着力（大于1,000 J/m2），肌腱对水凝胶的相对表面，我们显示与猪和人类肌腱准备在循环摩擦负荷。该水凝胶是生物相容的，牢固地粘附于活大鼠的髌骨、冈上肌和跟腱，在跟腱-肌腱断裂的大鼠模型中促进愈合并减少瘢痕形成，并且在髌腱损伤的大鼠模型中持续释放皮质类固醇曲安奈德，减少炎症，调节趋化因子分泌，募集肌腱干细胞和祖细胞，并促进巨噬细胞极化为M2表型。具有“Janus”表面和持续药物释放功能的水凝胶可以被设计用于一系列生物医学应用。
Hydrogels that provide mechanical support and sustainedly release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with surrounding tissue. Here, we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J/m2) to tendon on opposite surfaces of the hydrogel, as we show with porcine and human tendon preparations during cyclic-friction loadings. The hydrogel is biocompatible, strongly adheres to patellar, supraspinatus and Achilles tendons of live rats, boosted healing and reduced scar formation in a rat model of Achilles-tendon rupture, and sustainedly released the corticosteroid triamcinolone acetonide in a rat model of patellar tendon injury, reducing inflammation, modulating chemokine secretion, recruiting tendon stem and progenitor cells, and promoting macrophage polarization to the M2 phenotype. Hydrogels with ‘Janus’ surfaces and sustained-drug-release functionality could be designed for a range of biomedical applications.
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影响因子：
12.3
作者：
Carpenter AE;Jones TR;Lamprecht MR;Clarke C;Kang IH;Friman O;Guertin DA;Chang JH;Lindquist RA;Moffat J;Golland P;Sabatini DM
通讯作者：
Sabatini DM
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.
影响因子：
13.6
作者：
Blacklow, S. O.;Li, J.;Mooney, D. J.
通讯作者：
Mooney, D. J.
DOI：
10.1054/jhsb.1999.0279
发表时间：
1999-12-01
期刊：
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME
影响因子：
--
作者：
Evans, CE;Lees, GC;Trail, IA
通讯作者：
Trail, IA
影响因子：
2.8
作者：
Freedman, Benjamin R.;Zuskov, Andrey;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.