Thermosensitive Biodegradable Copper Sulfide Nanoparticles for Real-Time Multispectral Optoacoustic Tomography.
Thermosensitive Biodegradable Copper Sulfide Nanoparticles for Real-Time Multispectral Optoacoustic Tomography.
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DOI：
10.1021/acsabm.9b00133
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发表时间：
2019-08-19
影响因子：
4.7
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Shi S;Wen X;Li T;Wen X;Cao Q;Liu X;Liu Y;Pagel MD;Li C
尽管多功能无机纳米颗粒已被广泛探索用于有效的癌症诊断和治疗，但由于网状内皮系统中的显著摄取和对潜在毒性的担忧，其临床转化受到极大阻碍。在这项研究中，我们发现了CuS纳米粒子的热敏生物降解性，这一直被认为是经典的稳定在散装状态。聚乙二醇（PEG）包覆的CuS纳米颗粒（CuS-PEG）在4 ℃下保存良好，但在体外和体内测试中在37 ℃下1周内迅速降解。此外，实时多光谱光声断层扫描，这是更方便和准确的比传统的离体分析，成功地采用非侵入性地证明了CuS-PEG纳米粒子的生物降解性和动态监测其肿瘤成像能力。CuS-PEG纳米颗粒的温度依赖性可控降解特性和优异的肿瘤保留赋予它们巨大的临床应用潜力，因为它确保纳米颗粒在生产，运输和储存期间保持完整，但在完成足够的诊断和治疗操作后，在生理温度下降解并从体内清除。
Although multifunctional inorganic nanoparticles have been extensively explored for effective cancer diagnosis and therapy, their clinical translation has been greatly impeded because of significant uptake in the reticuloendothelial system and concerns about potential toxicity. In this study, we uncovered the thermosensitive biodegradability of CuS nanoparticles, which have classically been considered as stable in bulk state. Polyethylene glycol (PEG)-coated CuS nanoparticles (CuS-PEG) were well preserved at 4 ºC but were rapidly degraded at 37 ºC within 1 week in both in vitro and in vivo tests. Furthermore, real-time multispectral optoacoustic tomography, which is more convenient and accurate than traditional ex vivo analysis, was successfully employed to noninvasively demonstrate the biodegradability of CuS-PEG nanoparticles and dynamically monitor their tumor imaging capacity. The temperature-dependent controllable degradation profile and excellent tumor retention of CuS-PEG nanoparticles endows them with great potential for clinical applications since it ensures that the nanoparticles remain intact during production, transportation, and storage but degrade and clear from the body at physiological temperature after accomplishing sufficient diagnosis and therapeutic operations.
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影响因子：
46.2
作者：
Sharifi S;Behzadi S;Laurent S;Forrest ML;Stroeve P;Mahmoudi M
通讯作者：
Mahmoudi M
DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
17.1
作者：
Ku, Geng;Zhou, Min;Song, Shaoli;Huang, Qian;Hazle, John;Li, Chun
通讯作者：
Li, Chun
DOI：
10.1002/anie.201610649
发表时间：
2017-03-06
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Shi S;Xu C;Yang K;Goel S;Valdovinos HF;Luo H;Ehlerding EB;England CG;Cheng L;Chen F;Nickles RJ;Liu Z;Cai W
通讯作者：
Cai W
影响因子：
17.1
作者：
Foroutan, Farzad;Jokerst, Jesse V.;Gambhir, Sanjiv S.;Vermesh, Ophir;Kim, Hae-Won;Knowles, Jonathan C.
通讯作者：
Knowles, Jonathan C.