Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria.
Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria.
复制标题
DOI：
10.1016/j.chom.2022.02.001
复制
发表时间：
2022-03-09
影响因子：
30.3
通讯作者：
Martens, Eric C.
中科院分区：
文献类型：
--
作者：
Pudlo, Nicholas A.;Pereira, Gabriel Vasconcelos;Parnami, Jaagni;Cid, Melissa;Markert, Stephanie;Tingley, Jeffrey P.;Unfried, Frank;Ali, Ahmed;Varghese, Neha J.;Kim, Kwi S.;Campbell, Austin;Urs, Karthik;Xiao, Yao;Adams, Ryan;Martin, Duna;Bolam, David N.;Becher, Dorte;Eloe-Fadrosh, Emiley A.;Schmidt, Thomas M.;Abbott, D. Wade;Schweder, Thomas;Hehemann, Jan Hendrik;Martens, Eric C.
人类体内有许多种类的结肠细菌，它们能消化通常食用的陆生植物中的纤维多糖。最近在历史上，区域人群食用含有独特多糖的可食用大型海藻。目前尚不清楚肠道细菌如何广泛适应消化这些营养物质。在这里，我们表明肠道细菌消化海藻多糖的能力比以前认识到的更普遍。富集培养的拟杆菌含有先前发现的海藻降解基因，这些基因已经被动员到该属的几个成员中。此外，海洋细菌衍生基因的其他实例及其移动的DNA元件参与海藻多糖的肠道微生物降解，包括肠道驻留厚壁菌门中的基因。总的来说，这些结果揭示了多个独立的事件，这些事件已经动员了编码海藻降解酶的基因进入肠道细菌。这项工作进一步强调了人类肠道微生物组的代谢可塑性和饮食选择压力背景下的全球基因交换。历史上，几个地理区域的人类以寿司等形式食用海藻，将新型膳食纤维多糖引入肠道。Pudlo、佩雷拉等人表明，多种移动的DNA元件参与了海洋细菌基因的转移，使肠道细菌能够消化海藻多糖。
Humans harbor numerous species of colonic bacteria that digest fiber polysaccharides in commonly consumed terrestrial plants. More recently in history, regional populations have consumed edible macroalgae seaweeds containing unique polysaccharides. It remains unclear how extensively gut bacteria have adapted to digest these nutrients. Here, we show that the ability of gut bacteria to digest seaweed polysaccharides is more pervasive than previously appreciated. Enrichment-cultured Bacteroides harbor previously discovered genes for seaweed degradation, which have mobilized into several members of this genus. Additionally, other examples of marine bacteria-derived genes, and their mobile DNA elements, are involved in gut microbial degradation of seaweed polysaccharides, including genes in gut-resident Firmicutes. Collectively, these results uncover multiple separate events that have mobilized the genes encoding seaweed degrading-enzymes into gut bacteria. This work further underscores the metabolic plasticity of the human gut microbiome and global exchange of genes in the context of dietary selective pressures. Humans in several geographic regions have historically consumed seaweeds in forms like sushi, introducing novel dietary fiber polysaccharides to the gut. Pudlo, Pereira et al. show that a variety of mobile DNA elements have participated in transferring genes from marine bacteria, enabling gut bacteria to digest seaweed polysaccharides.
登录
查看更多内容
影响因子：
6.4
作者：
Clum A;Huntemann M;Bushnell B;Foster B;Foster B;Roux S;Hajek PP;Varghese N;Mukherjee S;Reddy TBK;Daum C;Yoshinaga Y;O'Malley R;Seshadri R;Kyrpides NC;Eloe-Fadrosh EA;Chen IA;Copeland A;Ivanova NN
通讯作者：
Ivanova NN
影响因子：
14.9
作者：
Drula E;Garron ML;Dogan S;Lombard V;Henrissat B;Terrapon N
通讯作者：
Terrapon N
影响因子：
6.8
作者：
Hehemann, Jan-Hendrik;Boraston, Alisdair B.;Czjzek, Mirjam
通讯作者：
Czjzek, Mirjam
影响因子：
11.2
作者：
Arata, Paula X.;Quintana, Irene;Ciancia, Marina
通讯作者：
Ciancia, Marina
影响因子：
14.9
作者：
Chen, I-Min A.;Chu, Ken;Kyrpides, Nikos C.
通讯作者：
Kyrpides, Nikos C.