The carbohydrate-active enzyme database: functions and literature.
The carbohydrate-active enzyme database: functions and literature.
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DOI：
10.1093/nar/gkab1045
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发表时间：
2022-01-07
影响因子：
14.9
通讯作者：
Terrapon N
中科院分区：
文献类型：
--
作者：
Drula E;Garron ML;Dogan S;Lombard V;Henrissat B;Terrapon N
自20多年前成为CAZy数据库的基于序列的家族中碳水化合物活性酶的分类出现以来，已经过去了30年，可在www.cazy.org上免费浏览和下载。在大规模测序和高通量生物学时代，重要的是要检查这个深深植根于人类策展的专业数据库的位置。CAZy管理员的三个主要任务是（i）维护和更新这类酶的家族分类，（ii）对GenBank和蛋白质数据库新发布的序列进行分类，以及（iii）捕获和呈现每个家族的功能信息。CAZy网站每月更新一次。在此，我们简要地总结了近8年来新家族的增加和注释。我们提出了几个重要的变化，促进分类导航，并允许下载整个注释。最重要的是，我们强调了大量的工作，伴随着从文献中的生化数据的分析和报告。
Thirty years have elapsed since the emergence of the classification of carbohydrate-active enzymes in sequence-based families that became the CAZy database over 20 years ago, freely available for browsing and download at www.cazy.org. In the era of large scale sequencing and high-throughput Biology, it is important to examine the position of this specialist database that is deeply rooted in human curation. The three primary tasks of the CAZy curators are (i) to maintain and update the family classification of this class of enzymes, (ii) to classify sequences newly released by GenBank and the Protein Data Bank and (iii) to capture and present functional information for each family. The CAZy website is updated once a month. Here we briefly summarize the increase in novel families and the annotations conducted during the last 8 years. We present several important changes that facilitate taxonomic navigation, and allow to download the entirety of the annotations. Most importantly we highlight the considerable amount of work that accompanies the analysis and report of biochemical data from the literature.
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影响因子：
5.9
作者：
Hettle, Andrew G.;Hobbs, Joanne K.;Boraston, Alisdair B.
通讯作者：
Boraston, Alisdair B.
饮食中的果糖聚糖会通过人类结肠菌属的协调酶途径降解。
影响因子：
28.3
作者：
Luis AS;Briggs J;Zhang X;Farnell B;Ndeh D;Labourel A;Baslé A;Cartmell A;Terrapon N;Stott K;Lowe EC;McLean R;Shearer K;Schückel J;Venditto I;Ralet MC;Henrissat B;Martens EC;Mosimann SC;Abbott DW;Gilbert HJ
通讯作者：
Gilbert HJ
影响因子：
14.9
作者：
Burley SK;Bhikadiya C;Bi C;Bittrich S;Chen L;Crichlow GV;Christie CH;Dalenberg K;Di Costanzo L;Duarte JM;Dutta S;Feng Z;Ganesan S;Goodsell DS;Ghosh S;Green RK;Guranović V;Guzenko D;Hudson BP;Lawson CL;Liang Y;Lowe R;Namkoong H;Peisach E;Persikova I;Randle C;Rose A;Rose Y;Sali A;Segura J;Sekharan M;Shao C;Tao YP;Voigt M;Westbrook JD;Young JY;Zardecki C;Zhuravleva M
通讯作者：
Zhuravleva M
影响因子：
14.9
作者：
Bairoch, A;Apweiler, R
通讯作者：
Apweiler, R
影响因子：
5.2
作者：
Schultz-Johansen M;Bech PK;Hennessy RC;Glaring MA;Barbeyron T;Czjzek M;Stougaard P
通讯作者：
Stougaard P