Maternal intestinal flora and wheeze in early childhood.
Maternal intestinal flora and wheeze in early childhood.
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孕产妇的肠道菌群和幼年时期的喘息。
DOI：
10.1111/j.1365-2222.2011.03950.x
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Litonjua AA
中科院分区：
文献类型：
--
作者：
Lange NE;Celedón JC;Forno E;Ly NP;Onderdonk A;Bry L;Delaney ML;DuBois AM;Gold DR;Weiss ST;Litonjua AA
越来越多的证据表明，婴儿时期肠道菌群改变与湿疹和哮喘有关。还没有研究调查母体肠道菌群对儿童早期喘息和湿疹的影响。目的探讨孕期母体肠道菌群与婴儿期喘息、湿疹发病的关系。来自波士顿地区的60名孕妇在怀孕后期提供粪便样本，并在怀孕期间回答有关自己健康的问题，以及在孩子2个月和6个月大时有关孩子健康的问题。对粪便标本进行定量培养，单位为log10个菌落形成单位(CFU)/克粪便。主要结果包括出生后前6个月的婴儿喘息和湿疹。特应性喘息被定义为喘息和湿疹，被分析为次要结果。在调整了母乳喂养、日托护理和母亲特应性的多因素模型中，母亲总需氧菌(TA)和肠球菌(E)计数较高与婴儿喘息的风险增加相关(TA：或2.32，CFU/g粪便增加1个对数[95%CI 1.22，4.42]；E：OR 1.57[95%CI 1.06，2.31])。没有微生物与湿疹或特应性喘息有关。在我们的队列中，母亲总需氧菌和肠球菌较高与婴儿喘息的风险增加有关。母体肠道菌群可能是早期免疫系统发育的重要环境暴露因素。
Increasing evidence links altered intestinal flora in infancy to eczema and asthma. No studies have investigated the influence of maternal intestinal flora on wheezing and eczema in early childhood. To investigate the link between maternal intestinal flora during pregnancy and development of wheeze and eczema in infancy. Sixty pregnant women from the Boston area gave stool samples during the third trimester of their pregnancy and answered questions during pregnancy about their own health, and about their children’s health when the child was 2 and 6 months of age. Quantitative culture was performed on stool samples and measured in log10colony-forming units(CFU)/gram stool. Primary outcomes included infant wheeze and eczema in the first 6 months of life. Atopic wheeze, defined as wheeze and eczema, was analyzed as a secondary outcome. In multivariate models adjusted for breastfeeding, daycare attendance and maternal atopy, higher counts of maternal total aerobes (TA) and enterococci (E) were associated with increased risk of infant wheeze (TA: OR 2.32 for 1 log increase in CFU/g stool [95% CI 1.22, 4.42]; E: OR 1.57 [95% CI 1.06, 2.31]). No organisms were associated with either eczema or atopic wheeze. In our cohort, higher maternal total aerobes and enterococci were related to increased risk of infant wheeze. Maternal intestinal flora may be an important environmental exposure in early immune system development.
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影响因子：
14.2
作者：
Gergen, Peter J.;Arbes, Samuel J., Jr.;Calatroni, Agustin;Mitchell, Herman E.;Zeldin, Darryl C.
通讯作者：
Zeldin, Darryl C.
影响因子：
14.2
作者：
Adlerberth, Ingegerd;Strachan, David P.;Wold, Agnes E.
通讯作者：
Wold, Agnes E.
影响因子：
4.2
作者：
Erickson, KL;Hubbard, NE
通讯作者：
Hubbard, NE
影响因子：
10.4
作者：
Duramad P;Harley K;Lipsett M;Bradman A;Eskenazi B;Holland NT;Tager IB
通讯作者：
Tager IB
影响因子：
105.7
作者：
Hatakka, K;Savilahti, E;Korpela, R
通讯作者：
Korpela, R