Power-frequency magnetic fields and childhood brain tumors: a case-control study in Japan.
Power-frequency magnetic fields and childhood brain tumors: a case-control study in Japan.
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DOI：
10.2188/jea.je20081017
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发表时间：
2010
影响因子：
4.7
通讯作者：
Kabuto M
中科院分区：
文献类型：
--
作者：
Saito T;Nitta H;Kubo O;Yamamoto S;Yamaguchi N;Akiba S;Honda Y;Hagihara J;Isaka K;Ojima T;Nakamura Y;Mizoue T;Ito S;Eboshida A;Yamazaki S;Sokejima S;Kurokawa Y;Kabuto M
儿童脑肿瘤与住宅工频磁场（MF）之间的关联强度在以前的研究中有所不同，这可能部分是由于MF暴露可能的错误分类。本研究旨在通过改进测量技术，并将测量扩展到整个星期，以检查日本的这种关联。这项基于人群的病例对照研究涵盖了54%的15岁以下日本儿童。在排除不合格的目标儿童后，55例新诊断的脑肿瘤病例和99例性别、年龄和居住区匹配的对照被纳入分析。每一组匹配的情况下，对照组的MF暴露量进行了测量，在时间上接近控制的季节性变化，平均差异为12.4天。诊断和MF测量之间的平均间隔为1.1年。每周平均MF水平定义为暴露量。使用控制了可能的混杂因素的条件logistic回归分析来评估这种关联。在调整母亲教育后，0.1至0.2、0.2至0.4和高于0.4 µT的暴露类别与<0.1 µT的参考类别的比值比（95%CI）分别为0.74（0.17-3.18）、1.58（0.25-9.83）和10.9（1.05-113）。当模型中纳入其他变量作为可能的混杂因素时，该剂量-反应模式稳定。研究发现，高水平的汞浓度（高于0.4 µ T）与患脑肿瘤的风险呈正相关。这种关联不能仅仅用混杂因素或选择偏倚来解释。
The strength of the association between brain tumors in children and residential power-frequency magnetic fields (MF) has varied in previous studies, which may be due in part to possible misclassification of MF exposure. This study aimed to examine this association in Japan by improving measurement techniques, and by extending measurement to a whole week. This population-based case-control study encompassed 54% of Japanese children under 15 years of age. After excluding ineligible targeted children, 55 newly diagnosed brain tumor cases and 99 sex-, age-, and residential area-matched controls were included in the analyses. The MF exposures of each set of matching cases and controls were measured in close temporal proximity to control for seasonal variation; the average difference was 12.4 days. The mean interval between diagnosis and MF measurements was 1.1 years. The weekly mean MF level was defined as the exposure. The association was evaluated using conditional logistic regression analysis that controlled for possible confounding factors. The odds ratios (95% CI) for exposure categories of 0.1 to 0.2, 0.2 to 0.4, and above 0.4 µT, against a reference category of <0.1 µT, were 0.74 (0.17–3.18), 1.58 (0.25–9.83), and 10.9 (1.05–113), respectively, after adjusting for maternal education. This dose-response pattern was stable when other variables were included in the model as possible confounding factors. A positive association was found between high-level exposure—above 0.4 µT—and the risk of brain tumors. This association could not be explained solely by confounding factors or selection bias.
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影响因子：
5.4
作者：
Mezei, Gabor;Gadallah, May;Kheifets, Leeka
通讯作者：
Kheifets, Leeka
影响因子：
1
作者：
Swanson, J
通讯作者：
Swanson, J
影响因子：
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Verkasalo, PK
影响因子：
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作者：
FEYCHTING, M;AHLBOM, A
通讯作者：
AHLBOM, A
影响因子：
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作者：
OLSEN, JH;NIELSEN, A;SCHULGEN, G
通讯作者：
SCHULGEN, G