Interferon-γ and interleukin-4 detected in serum and saliva from patients with oral lichen planus.
Interferon-γ and interleukin-4 detected in serum and saliva from patients with oral lichen planus.
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DOI：
10.1038/ijos.2013.74
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发表时间：
2014-03
影响因子：
14.9
通讯作者：
Chen, Qian-Ming
中科院分区：
文献类型：
--
作者：
Liu, Wen-Zhao;He, Ming-Jing;Long, Long;Mu, Dong-Liang;Xu, Ming-Shu;Xing, Xue;Zeng, Xin;Liao, Ga;Dan, Hong-Xia;Chen, Qian-Ming
我们先前的唾液研究表明，口腔扁平苔藓(OLP)患者唾液中存在明显的辅助性T细胞2(Th2)优势，提示唾液白细胞介素4(IL-4)有可能成为监测疾病严重程度的生物标志物。为了进一步确定口腔扁平苔藓患者Th1/Th2偏向的一致性，本研究观察了口腔扁平苔藓患者血清中干扰素-γ和IL-4的表达谱，并探讨了这两种细胞因子水平与唾液的关系。本研究以60例中国人口腔扁平苔藓患者为研究对象，其中40例为红斑/溃疡型，20例为网状型，另40例年龄、性别相匹配的健康志愿者为对照组。采用酶联免疫吸附试验检测血清和配对唾液中干扰素-γ和白介素4水平。口腔扁平苔藓患者血清和唾液中均存在低水平的干扰素-γ和高水平的IL-4表达，且干扰素-γ/IL-4比值较低。红斑/溃疡组血清IL-4水平显著高于网状组。血清干扰素-γ和IL-4水平与唾液配对呈显著正相关。这些结果为口腔扁平苔藓中Th2细胞因子主导的免疫失衡以及IL-4作为监测口腔扁平苔藓严重程度的生物标志物的潜力提供了更多的证据。
Our previous salivary study had demonstrated an apparent T helper 2 (Th2)-predominance in saliva of oral lichen planus (OLP) patients and suggested a potential of salivary interleukin-4 (IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-γ (IFN-γ) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP (40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age–sex-matched healthy volunteers as control group. IFN-γ and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-γ but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-γ/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-γ and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokine-predominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP.
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影响因子：
3.8
作者：
Tao, X-a;Xia, J.;Cheng, B.
通讯作者：
Cheng, B.
口腔扁平苔藓患者病灶组织和未刺激唾液中IFN-γ和IL-4的同时检测
影响因子：
3.3
作者：
Tao, Xiao-an;Li, Chun-yang;Cheng, Bin
通讯作者：
Cheng, Bin
影响因子：
82.9
作者：
Ghoreschi, K;Thomas, P;Röcken, M
通讯作者：
Röcken, M
影响因子：
3.3
作者：
Khan, A;Farah, CS;Sugerman, PB
通讯作者：
Sugerman, PB
影响因子：
4.6
作者：
Rhodus NL;Cheng B;Ondrey F
通讯作者：
Ondrey F