Cytokine profiling of young overweight and obese female African American adults with prediabetes.
Cytokine profiling of young overweight and obese female African American adults with prediabetes.
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DOI：
10.1016/j.cyto.2013.05.025
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发表时间：
2013-10
期刊：
影响因子：
3.8
通讯作者：
Dong, Yanbin
中科院分区：
文献类型：
--
作者：
Lucas, Rudolf;Parikh, Samip J.;Sridhar, Supriya;Guo, De-Huang;Bhagatwala, Jigar;Dong, Yutong;Caldwell, Ruth;Mellor, Andrew;Caldwell, William;Zhu, Haidong;Dong, Yanbin
每年约有5-10%的前驱糖尿病患者成为糖尿病患者。炎症与肥胖相关的2型糖尿病（T2 D）的发展有关。然而，迄今为止，炎症与糖尿病前期（定义为血红蛋白A1 c（HbA 1c）≥ 5.7且<6.5%）之间的关系在很大程度上仍未得到探索，特别是在非洲裔美国人中。因此，在这项研究中，我们研究了一个全面的面板13个细胞因子参与炎症反应的超重/肥胖的受试者与糖尿病前期。本研究共选择了21名其他方面健康、超重/肥胖、患有糖尿病前期的年轻成年非裔美国女性，以及20名匹配的超重/肥胖对照。通过多重细胞因子分析评估血浆细胞因子。与对照组相比，糖尿病前期组的白细胞介素（IL）-5，IL-6，IL-7，肿瘤坏死因子-α（TNF-α）和粒细胞-单核细胞集落刺激因子（GM-CSF）的血浆浓度显著升高（均p < 0.05）。所有其他细胞因子，干扰素-γ（IFN-γ）、IL-1β、IL-2、IL-4、IL-8、IL-10、IL-12 p70和IL-13的血浆浓度似乎在前驱糖尿病组中升高，但未达到统计学显著性。合并两组后，发现HbA 1c与IFN- γ、IL-1β、IL-2、IL-5、IL-7、IL-8、TNF-α和GM-CSF呈正相关。这项研究表明，超重/肥胖的糖尿病前期年轻受试者中各种促炎细胞因子水平升高，这使他们患T2 D和心血管疾病的风险更高。我们的数据还需要在动物模型和人群队列中进行进一步研究，以确定各种促炎细胞因子在肥胖相关T2 D早期发展中的作用。
Approximately 5–10% of subjects with prediabetes become diabetic every year. Inflammation is involved in the development of obesity-related type 2 diabetes (T2D). However, to date, the relationship between inflammation and prediabetes, defined by hemoglobin A1c (HbA1c) ≥ 5.7 and < 6.5%, remains largely unexplored, especially in African Americans. Therefore, in this study we examined a comprehensive panel of 13 cytokines involved in the inflammatory response in overweight/obese subjects with prediabetes. A total of 21 otherwise healthy, overweight/obese, young adult African American females with prediabetes, together with 20 matched overweight/obese controls, were selected for this study. Plasma cytokines were assessed by multiplex cytokine profiling. Plasma concentrations of interleukin (IL)-5, IL-6, IL-7, tumor necrosis factor-α (TNF-α), and granulocyte-monocyte colony-stimulating factor (GM-CSF) were significantly higher in the prediabetic group, as compared to the control group (all p < 0.05). Plasma concentrations of all the other cytokines, interferon-γ (IFN-γ), IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12p70 and IL-13, seemed to be elevated in the prediabetic group, but failed to reach statistical significances. Upon merging both groups, HbA1c was found to be positively correlated with IFN- γ, IL-1β, IL-2, IL-5, IL-7, IL-8, TNF-α and GM-CSF. This study demonstrates elevated levels of various pro-inflammatory cytokines in overweight/obese young subjects with prediabetes, which place them at higher risk of developing T2D and cardiovascular diseases. Our data also call for further investigations in animal models and population cohorts to establish the roles of a variety of pro-inflammatory cytokines in the early development of obesity-related T2D.
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影响因子：
2.2
作者：
Konukoglu, D;Hatemi, H;Bagriaçik, N
通讯作者：
Bagriaçik, N
DOI：
10.1073/pnas.1121075109
发表时间：
2012-02-07
影响因子：
11.1
作者：
Lucas, Rudolf;Sridhar, Supriya;Schally, Andrew V.
通讯作者：
Schally, Andrew V.
DOI：
10.1186/1476-9255-7-36
发表时间：
2010-07-26
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Gupta AK;Johnson WD
通讯作者：
Johnson WD
影响因子：
2.2
作者：
Arnalich, F;Hernanz, A;Montiel, C
通讯作者：
Montiel, C
影响因子：
5.1
作者：
Choi, KM;Lee, J;Baik, SH
通讯作者：
Baik, SH