The descriptive epidemiology of epilepsy-a review.

The descriptive epidemiology of epilepsy-a review.
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DOI:
10.1016/j.eplepsyres.2009.03.003
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发表时间:
2009-07
期刊:
影响因子:
2.2
通讯作者:
Hauser, W. Allen
Hauser, W. Allen
中科院分区:
医学4区
文献类型:
--
作者:
Banerjee, Poonam Nina;Filippi, David;Hauser, W. Allen

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癫痫是数百万人经历的一种慢性疾病,是造成大量发病率和死亡率的原因之一。本综述总结了癫痫的患病率和发病率研究,这些研究提供了癫痫的明确定义,并且可以进行年龄调整:如果要进行研究间的比较。尽管很少有例外,但基于记录的研究得出的年龄调整患病率估计值(每1000人2.7至17.6人)低于挨家挨户调查得出的估计值(每1000人2.2至41.0人)。年龄调整后的发病率从每10万人16至51人不等,智利有一个例外,发病率为每10万人111人。报告的患病率和发病率的差异可能与获得卫生保健、区域环境暴露或社会经济地位等因素有关。在大多数流行病学研究中,以全身性发作为特征的癫痫的比例较高。以部分性发作为特征的癫痫占癫痫事件的20%至66%。几乎所有的患病率和发病率研究都报告了不明原因的癫痫发作的优势。在没有数据的区域需要进行更多的流行率研究,在所有区域需要进行更多的发病率研究。解释患病率和发病率的差异需要了解影响癫痫及其护理的文化、社会和经济因素的作用。
Epilepsy is a chronic disease experienced by millions and a cause of substantial morbidity and mortality. This review summarizes prevalence and incidence studies of epilepsy that provided a clear definition of epilepsy and could be age-adjusted: requirements if comparisons across studies are to be made. Although few exceptions, age-adjusted prevalence estimates from record-based studies (2.7 to 17.6 per 1000), are lower than those from door-to-door surveys (2.2 to 41.0 per 1000). Age-adjusted incidence ranged from 16 to 51 per 100,000, with one exception in Chile, where incidence was 111 per 100,000. Variation in reported prevalence and incidence may be related to factors such as access to health care, regional environmental exposures, or socioeconomic status. A higher proportion of epilepsy characterized by generalized seizures was reported in most prevalence studies. Epilepsy characterized by partial seizures accounted for 20% to 66% of incident epilepsies. Virtually all prevalence and incidence studies report a preponderance of seizures of unknown cause. Additional prevalence studies are needed in regions where data does not exist, and additional incidence studies in all regions. Interpretation of differences in prevalence and incidence will require understanding of the role of cultural, social and economic factors influencing epilepsy and its care.
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发表时间: 1995-05-01
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