An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits.
An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits.
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DOI：
10.1016/j.nicl.2018.01.027
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Viding E
中科院分区：
文献类型：
--
作者：
Sethi A;O'Nions E;McCrory E;Bird G;Viding E
移情能力部分依赖于用自己的情感体验来模拟他人的情感体验。这个过程由许多大脑区域支持，包括前额叶皮层（AI），前扣带皮层（ACC），内侧前额叶皮层（mPFC）和杏仁核。有行为问题（CP）的儿童，特别是那些具有高水平冷酷无情特质（CP/HCU）的儿童，与同龄人相比，他们的同情心更少。当他们看到其他人处于痛苦中时，支持移情处理的区域的神经反应也会减少。目前的研究集中在识别在情感内省过程中共同激活的大脑区域：i）一个人自己的情绪（二）他人的情绪（“其他情绪”）;以及iii）一个人对他人情绪的感受（“感受他人”）在典型发育男孩的恐惧与中性情景中（TD; n = 31），CP/HCU男孩（n = 31），CP和低水平CU男孩（CP/LCU; n = 33）。TD组内各种条件的联合分析显示，AI、ACC/mPFC和枕叶皮质中存在显著的激活簇。在CP/HCU和CP/LCU组的条件下进行的连接分析没有将这些区域确定为显著激活。然而，随访分析无法证实整个网络中组间的统计学显著差异，贝叶斯因子分析未为零假设或替代假设提供实质性支持。事后比较表明，CP/HCU组中缺乏连接效应可能反映了在“其他情绪”和“感觉其他”条件下情感内省的减少，以及在CP/LCU组中“自己的情绪”条件下情感内省的减少。这些研究结果提供了有限的，最终模棱两可的证据，改变对他人的情感内省在CP/HCU，改变自己的情绪在CP/LCU的情感内省，并强调需要进一步的研究，系统地调查共情赤字的确切性质与CP儿童。在典型发育的儿童中检测到一个核心情感内省网络，当内省他们的情绪，另一个人的情绪，或者他们对另一个人的感觉如何，这个网络在有行为问题的儿童中并没有被一致地检测到，但是直接比较无法检测到群体之间这个网络的显着差异，未来的工作必须仔细评估和比较深思熟虑和偶然的社会问题。这些孩子的情感处理
The ability to empathise relies in part on using one's own affective experience to simulate the affective experience of others. This process is supported by a number of brain areas including the anterior insula (AI), anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), and the amygdala. Children with conduct problems (CP), and in particular those with high levels of callous-unemotional traits (CP/HCU) present with less empathy than their peers. They also show reduced neural response in areas supporting empathic processing when viewing other people in distress. The current study focused on identifying brain areas co-activated during affective introspection of: i) One's own emotions (‘Own emotion’); ii) Others' emotions (‘Other emotion’); and iii) One's feelings about others' emotions (‘Feel for other’) during fearful vs neutral scenarios in typically developing boys (TD; n = 31), boys with CP/HCU (n = 31), and boys with CP and low levels of CU (CP/LCU; n = 33). The conjunction analysis across conditions within the TD group revealed significant clusters of activation in the AI, ACC/mPFC, and occipital cortex. Conjunction analyses across conditions in the CP/HCU and CP/LCU groups did not identify these areas as significantly activated. However, follow-up analyses were not able to confirm statistically significant differences between groups across the whole network, and Bayes-factor analyses did not provide substantial support for either the null or alternate hypotheses. Post-hoc comparisons indicated that the lack of conjunction effects in the CP/HCU group may reflect reduced affective introspection in the ‘Other emotion’ and ‘Feel for other’ conditions, and by reduced affective introspection in the ‘Own emotion’ condition in the CP/LCU group. These findings provide limited and ultimately equivocal evidence for altered affective introspection regarding others in CP/HCU, and altered affective introspection for own emotions in CP/LCU, and highlight the need for further research to systematically investigate the precise nature of empathy deficits in children with CP. A core affective introspective network was detected in typically developing children This was active when introspecting about their emotions, another's emotions, or how they felt for another This network was not consistently detected in children with conduct problems Direct comparisons were however unable to detect significant differences in this network between groups Future work must carefully assess and compare deliberative and incidental socio-affective processing in these children
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
DOI：
10.1093/brain/awt190
发表时间：
2013-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Meffert H;Gazzola V;den Boer JA;Bartels AA;Keysers C
通讯作者：
Keysers C
影响因子：
3.1
作者：
Medford, Nick;Critchley, Hugo D.
通讯作者：
Critchley, Hugo D.
影响因子：
9.2
作者：
Lockwood, Patricia L.;Sebastian, Catherine L.;McCrory, Eamon J.;Hyde, Zoe H.;Gu, Xiaosi;De Brito, Stephane A.;Viding, Essi
通讯作者：
Viding, Essi
影响因子：
5
作者：
Seara-Cardoso, Ana;Viding, Essi
通讯作者：
Viding, Essi