Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans.
Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans.
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DOI：
10.2337/db12-0025
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发表时间：
2012-09
期刊：
影响因子：
7.7
通讯作者：
Oltmanns KM
中科院分区：
文献类型：
--
作者：
Jauch-Chara K;Friedrich A;Rezmer M;Melchert UH;G Scholand-Engler H;Hallschmid M;Oltmanns KM
脑胰岛素对人和动物都有厌食作用。然而，潜在的机制尚不清楚。由于胰岛素在生理上促进了身体大多数组织对葡萄糖的吸收，从而促进了细胞内的能量供应，因此我们假设鼻内胰岛素通过提高神经能量水平来减少食物消耗。在一项双盲、安慰剂对照的受试者内部比较中，15名年龄在22-28岁的健康男性(BMI 22.2±0.37公斤/平方米)在隔夜禁食后接受了胰岛素(40IU)或安慰剂的鼻腔注射。用31P磁共振波谱评价脑组织能量代谢。在喷雾后100分钟，参与者从测试自助餐中随意食用。我们的数据显示，鼻腔胰岛素增加了大脑能量(即三磷酸腺苷和磷酸肌酸水平)。在对照条件下，大脑能量含量与随后的卡路里摄入量呈负相关。此外，服用胰岛素后神经能量的增加与自由选择卡路里消耗的连续减少相关。因此，大脑能量水平可能构成食物摄入量的预测值。鉴于大脑根据其当前的能量状态同步食物摄取行为，肥胖症治疗的未来挑战可能是从治疗上影响大脑能量稳态。鼻腔胰岛素在优化其应用方案后，在这方面似乎是一个有前途的选择。
Cerebral insulin exerts anorexic effects in humans and animals. The underlying mechanisms, however, are not clear. Because insulin physiologically facilitates glucose uptake by most tissues of the body and thereby fosters intracellular energy supply, we hypothesized that intranasal insulin reduces food consumption via enhancement of the neuroenergetic level. In a double-blind, placebo–controlled, within-subject comparison, 15 healthy men (BMI 22.2 ± 0.37 kg/m2) aged 22–28 years were intranasally administered insulin (40 IU) or placebo after an overnight fast. Cerebral energy metabolism was assessed by 31P magnetic resonance spectroscopy. At 100 min after spray administration, participants consumed ad libitum from a test buffet. Our data show that intranasal insulin increases brain energy (i.e., adenosine triphosphate and phosphocreatine levels). Cerebral energy content correlates inversely with subsequent calorie intake in the control condition. Moreover, the neuroenergetic rise upon insulin administration correlates with the consecutive reduction in free-choice calorie consumption. Brain energy levels may therefore constitute a predictive value for food intake. Given that the brain synchronizes food intake behavior in dependence of its current energetic status, a future challenge in obesity treatment may be to therapeutically influence cerebral energy homeostasis. Intranasal insulin, after optimizing its application schema, seems a promising option in this regard.
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