Traumatic brain injury-induced cerebral microbleeds in the elderly.
Traumatic brain injury-induced cerebral microbleeds in the elderly.
复制标题
老年人创伤性脑损伤所致脑微出血。
DOI:
10.1007/s11357-020-00280-3
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发表时间:
2021-03
期刊:
影响因子:
5.6
通讯作者:
Toth P
中科院分区:
文献类型:
--
作者:
Toth L;Czigler A;Horvath P;Kornyei B;Szarka N;Schwarcz A;Ungvari Z;Buki A;Toth P
Traumatic brain injury (TBI) was shown to lead to the development of cerebral microbleeds (CMBs), which are associated with long term cognitive decline and gait disturbances in patients. The elderly is one of the most vulnerable parts of the population to suffer TBI. Importantly, ageing is known to exacerbate microvascular fragility and to promote the formation of CMBs. In this overview, the effect of ageing is discussed on the development and characteristics of TBI-related CMBs, with special emphasis on CMBs associated with mild TBI. Four cases of TBI-related CMBs are described to illustrate the concept that ageing exacerbates the deleterious microvascular effects of TBI and that similar brain trauma may induce more CMBs in old patients than in young ones. Recommendations are made for future prospective studies to establish the mechanistic effects of ageing on the formation of CMBs after TBI, and to determine long-term consequences of CMBs on clinically relevant outcome measures including cognitive performance, gait and balance function.
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影响因子:
4.7
作者:
DiSabato DJ;Quan N;Godbout JP
通讯作者:
Godbout JP
DOI:
10.1186/1757-7241-22-7
发表时间:
2014-01-28
期刊:
Scandinavian journal of trauma, resuscitation and emergency medicine
影响因子:
--
作者:
Cheng PL;Lin HY;Lee YK;Hsu CY;Lee CC;Su YC
通讯作者:
Su YC
DOI:
10.1177/1073858410397054
发表时间:
2012-02
期刊:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子:
--
作者:
Erickson KI;Miller DL;Roecklein KA
通讯作者:
Roecklein KA
影响因子:
--
作者:
DroyLefaix, MT
通讯作者:
DroyLefaix, MT
影响因子:
2.8
作者:
de Haan, S.;de Groot, J. C.;van der Naalt, J.
通讯作者:
van der Naalt, J.