Traumatic brain injury-induced cerebral microbleeds in the elderly.

Traumatic brain injury-induced cerebral microbleeds in the elderly.
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老年人创伤性脑损伤所致脑微出血。

DOI:
10.1007/s11357-020-00280-3
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发表时间:
2021-03
期刊:
影响因子:
5.6
通讯作者:
Toth P
Toth P
中科院分区:
医学1区
文献类型:
--
作者:
Toth L;Czigler A;Horvath P;Kornyei B;Szarka N;Schwarcz A;Ungvari Z;Buki A;Toth P

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创伤性脑损伤(TBI)可导致脑微出血(CMB)的发生,这与患者的长期认知能力下降和步态障碍有关。老年人是最容易遭受TBI的人群之一。重要的是,已知衰老会加剧微血管脆弱性并促进CMB的形成。在这篇综述中,老化的影响进行了讨论TBI相关的CMB的发展和特点,特别强调与轻度TBI相关的CMB。描述了四例TBI相关CMB,以说明老龄化加剧TBI的有害微血管效应的概念,类似的脑外伤可能会诱导更多的CMB在老年患者比年轻的。建议为未来的前瞻性研究,以建立老化的机械影响,对形成的CMB TBI后,并确定长期的临床相关的结果措施,包括认知能力,步态和平衡功能的CMB的后果。
Traumatic brain injury (TBI) was shown to lead to the development of cerebral microbleeds (CMBs), which are associated with long term cognitive decline and gait disturbances in patients. The elderly is one of the most vulnerable parts of the population to suffer TBI. Importantly, ageing is known to exacerbate microvascular fragility and to promote the formation of CMBs. In this overview, the effect of ageing is discussed on the development and characteristics of TBI-related CMBs, with special emphasis on CMBs associated with mild TBI. Four cases of TBI-related CMBs are described to illustrate the concept that ageing exacerbates the deleterious microvascular effects of TBI and that similar brain trauma may induce more CMBs in old patients than in young ones. Recommendations are made for future prospective studies to establish the mechanistic effects of ageing on the formation of CMBs after TBI, and to determine long-term consequences of CMBs on clinically relevant outcome measures including cognitive performance, gait and balance function.
DOI: 10.1111/jnc.13607
发表时间: 2016-10
影响因子: 4.7
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