Assessing rodent hippocampal involvement in the novel object recognition task. A review.
Assessing rodent hippocampal involvement in the novel object recognition task. A review.
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DOI：
10.1016/j.bbr.2014.08.002
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发表时间：
2015-05-15
影响因子：
2.7
通讯作者：
Stackman RW Jr
中科院分区：
文献类型：
--
作者：
Cohen SJ;Stackman RW Jr
新颖的物体识别（NOR）任务已成为测试啮齿类动物非空间记忆神经生物学的流行方法。这项任务利用了啮齿动物探索新事物的自然倾向，并且根据啮齿动物探索所呈现的物体所花费的时间，可以建立关于记忆的推论。尽管它被广泛使用，但支持 NOR 的底层神经回路和机制尚未明确定义。特别是，相当多的争论集中在海马体是否在 NOR 任务的离散阶段中编码、巩固和检索的对象记忆中发挥重要作用。在这里，我们分析了所有已发表报告的结果，其中啮齿动物海马在物体记忆中的作用是根据参数受限的任务表现推断出来的。我们注意到，不同研究中 NOR 方法的显着差异使得从工作中得出有意义的结论的能力变得复杂。重点关注 12 份报告，其中施加了样本会话对象探索的最低标准，我们发现，当样本会话和测试会话之间施加 10 分钟或更长的延迟时，海马体的临时或永久性损伤始终会扰乱对象记忆。我们讨论了内侧颞叶框架内海马在 NOR 中的延迟依赖性作用的重要性。我们断言，NOR 协议的标准化对于获得可靠的数据至关重要，然后可以在研究之间进行比较，以就啮齿动物海马体对对象记忆的具体贡献达成共识。
The novel object recognition (NOR) task has emerged as a popular method for testing the neurobiology of nonspatial memory in rodents. This task exploits the natural tendency of rodents to explore novel items and depending on the amount of time that rodents spend exploring the presented objects, inferences about memory can be established. Despite its wide use, the underlying neural circuitry and mechanisms supporting NOR have not been clearly defined. In particular, considerable debate has focused on whether the hippocampus plays a significant role in the object memory that is encoded, consolidated and then retrieved during discrete stages of the NOR task. Here we analyzed the results of all published reports in which the role of the rodent hippocampus in object memory was inferred from performance in the task with restricted parameters. We note that the remarkable variability in NOR methods across studies complicates the ability to draw meaningful conclusions from the work. Focusing on twelve reports in which a minimum criterion of sample session object exploration was imposed, we find that temporary or permanent lesion of the hippocampus consistently disrupts object memory when a delay of 10 min or greater is imposed between the sample and test sessions. We discuss the significance of a delay-dependent role of the hippocampus in NOR within the framework of the medial temporal lobe. We assert that standardization of the NOR protocol is essential for obtaining reliable data that can then be compared across studies to build consensus as to the specific contribution of the rodent hippocampus to object memory.
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