Nanotechnology in interventional cardiology.
Nanotechnology in interventional cardiology.
复制标题
DOI：
10.1002/wnan.154
复制
发表时间：
2012-01
影响因子：
8.6
通讯作者：
Lanza, Gregory M.
中科院分区：
文献类型：
--
作者：
Cyrus, Tillmann;Wickline, Samuel A.;Lanza, Gregory M.
通过一次或一系列的球囊血管成形术，高度动脉粥样硬化性狭窄可以减少到零或最小的残余狭窄级别。目前，植入支架是为了防止血管立即回缩，从支架支架中洗脱抗有丝分裂药物可以最大限度地减少再狭窄。这种药物洗脱的一个不良副作用是延迟再内皮化，这需要在许多情况下使用两种抗血小板药物治疗至少一年，以防止急性支架内血栓形成。支架设计和药物洗脱技术的进步，目前已进入第四代，但并未减弱这一问题。基于纳米技术的局部药物输送具有在不阻碍内皮愈合的同时实现预防再狭窄的潜力。分子靶向药物可以与受损的介质和外膜中的表位特异性结合。因此，内皮修复可能不受阻碍地进行。为了防止再狭窄，这项技术可以与裸金属支架或可生物降解支架一起使用。在这篇文章中，将比较新的纳米粒子制剂在将药物输送到血管壁内的分子靶点方面的潜力。将对潜在的分子靶点、靶向机制、药物递送倾向和生物相容性进行综述。
High-grade atherosclerotic stenoses are reduced to zero or minimal residual stenosis grades by a single or a series of balloon angioplasties. Currently, stents are implanted to prevent immediate vascular recoil and elution of an anti-mitotic drug from the stent struts minimizes restenosis. An unwanted side-effect of this drug-elution is delayed re-endothelialization which requires the treatment with two anti-platelet drugs in many cases for a minimum of one year to prevent acute in-stent thrombosis. Advances in stent-design and drug-elution technology, now in its fourth generation, have not abated this issue. Nanotechnology-based local drug delivery has the potential to achieve restenosis prevention while not impeding endothelial healing. Molecularly targeted drugs can be aimed to specifically bind to epitopes in the injured media and adventitia. Thus, endothelial healing may progress unhindered. To prevent restenosis, this technology may be used with bare metal or biodegradable stents. In this article novel nanoparticulate agents will be compared regarding their potential to deliver drugs to molecular targets within the vascular wall. Potential molecular targets, targeting mechanisms, drug-delivery propensities, and biocompatibility will be reviewed.
登录
查看更多内容
影响因子：
168.9
作者：
Daemen, Joost;Wenaweser, Peter;Serruys, Patrick W.
通讯作者：
Serruys, Patrick W.
影响因子：
10.8
作者：
Frias, Juan C.;Ma, Yanqing;Fisher, Edward A.
通讯作者：
Fisher, Edward A.
DOI：
10.1016/j.jconrel.2010.10.025
发表时间：
2011-02-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Calderon AJ;Bhowmick T;Leferovich J;Burman B;Pichette B;Muzykantov V;Eckmann DM;Muro S
通讯作者：
Muro S
影响因子：
15
作者：
Frias, JC;Williams, KJ;Fayad, ZA
通讯作者：
Fayad, ZA
影响因子：
10.8
作者：
Cormode DP;Skajaa T;van Schooneveld MM;Koole R;Jarzyna P;Lobatto ME;Calcagno C;Barazza A;Gordon RE;Zanzonico P;Fisher EA;Fayad ZA;Mulder WJ
通讯作者：
Mulder WJ