Vascular uptake on (18)F-sodium fluoride positron emission tomography: precursor of vascular calcification?
Vascular uptake on (18)F-sodium fluoride positron emission tomography: precursor of vascular calcification?
复制标题
DOI：
10.1007/s12350-020-02031-5
复制
发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
de Jong PA
中科院分区：
文献类型：
--
作者：
den Harder AM;Wolterink JM;Bartstra JW;Spiering W;Zwakenberg SR;Beulens JW;Slart RHJA;Luurtsema G;Mali WP;de Jong PA
目前的CT分辨率不能识别微钙化；然而，18F-氟化钠(18F-NaF)正电子发射断层扫描(PET)成像已被提出用于无创性识别微钙化。这项研究的主要目的是评估18F-NaF活性是否可以评估CT可检测到的血管钙化的存在和预测进展。采用两项纵向研究的数据，患者在基线和6个月或1年后接受18F-NaF PET-CT检查。在基线和随访时，在PET上测量靶与背景比(TBR)，并对股动脉的CT钙化进行量化。纳入128例患者。基线时较高的总胆红素与基线时较高的钙化肿块和钙化进展相关(在随访6个月和1年的研究中，β=1.006[1.005-1.007]和β=1.002[1.002-1.003])。在基线上没有钙化的区域和在随访中发生钙化的区域，与没有发生钙化的区域相比，TBR高出0.11-0.13(P<0.01)。18F-NaF活性与钙化量及钙化进程有关。在发生钙化形成的区域，TBR略高但明显高。本文的在线版本(10.1007/s12350-020-02031-5)包含向授权用户提供的补充材料。
Microcalcifications cannot be identified with the present resolution of CT; however, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification. The primary objective of this study was to assess whether 18F-NaF activity can assess the presence and predict the progression of CT detectable vascular calcification. The data of two longitudinal studies in which patients received a 18F-NaF PET-CT at baseline and after 6 months or 1-year follow-up were used. The target to background ratio (TBR) was measured on PET at baseline and CT calcification was quantified in the femoral arteries at baseline and follow-up. 128 patients were included. A higher TBR at baseline was associated with higher calcification mass at baseline and calcification progression (β = 1.006 [1.005-1.007] and β = 1.002 [1.002-1.003] in the studies with 6 months and 1-year follow-up, respectively). In areas without calcification at baseline and where calcification developed at follow-up, the TBR was .11–.13 (P < .001) higher compared to areas where no calcification developed. The activity of 18F-NaF is related to the amount of calcification and calcification progression. In areas where calcification formation occurred, the TBR was slightly but significantly higher. The online version of this article (10.1007/s12350-020-02031-5) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
5.3
作者：
de Oliveira-Santos, Manuel;Castelo-Branco, Miguel;Ferreira, Maria Joao
通讯作者：
Ferreira, Maria Joao
DOI：
10.1007/s00259-017-3680-x
发表时间：
2017-08-01
影响因子：
9.1
作者：
Ishiwata, Yoshinobu;Kaneta, Tomohiro;Inoue, Tomio
通讯作者：
Inoue, Tomio
影响因子：
20.1
作者：
Herrington, William;Lacey, Ben;Lewington, Sarah
通讯作者：
Lewington, Sarah
影响因子：
1.5
作者：
Li, Yuxin;Berenji, Gholam R.;Dadparvar, Simin
通讯作者：
Dadparvar, Simin
影响因子：
16.2
作者：
NISKANEN, L;SIITONEN, O;UUSITUPA, MI
通讯作者：
UUSITUPA, MI