A comparison of functional brain changes associated with surgical versus behavioral weight loss.
A comparison of functional brain changes associated with surgical versus behavioral weight loss.
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DOI：
10.1002/oby.20630
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发表时间：
2014-02
期刊：
影响因子：
6.9
通讯作者：
Savage, Cary R.
中科院分区：
文献类型：
--
作者：
Bruce, Amanda S.;Bruce, Jared M.;Ness, Abigail R.;Lepping, Rebecca J.;Malley, Stephen;Hancock, Laura;Powell, Josh;Patrician, Trisha M.;Breslin, Florence J.;Martin, Laura E.;Donnelly, Joseph E.;Brooks, William M.;Savage, Cary R.
很少有研究检查大脑对有效减肥的反应;没有人比较不同的减肥干预方法。我们比较了行为减肥干预与减肥手术相关的脑功能变化。在可调节胃束带手术之前招募了15名肥胖参与者，在行为饮食干预之前招募了16名肥胖参与者。各组的人口统计学数据和体重减轻量相匹配。在手术/行为干预之前和之后12周进行fMRI扫描（饥饿时和饭后的视觉食物动机范例）。在餐前分析中，与肥胖患者相比，行为节食者在体重减轻后右内侧PFC和左楔前叶对食物图像的激活增加。与行为节食者相比，减肥患者在体重减轻后双侧颞叶皮层的激活增加。与肥胖患者相比，行为节食者对内侧PFC（与自我指涉信息的评估和处理相关的区域）的食物线索的反应增加。与行为节食者相比，肥胖症患者大脑中与更高水平感知相关的区域对食物提示的反应增强。减肥的方法决定了大脑功能的独特变化。
Few studies have examined brain changes in response to effective weight loss; none have compared different methods of weight-loss intervention. We compared functional brain changes associated with a behavioral weight loss intervention to those associated with bariatric surgery. 15 obese participants were recruited prior to adjustable gastric banding surgery and 16 obese participants were recruited prior to a behavioral diet intervention. Groups were matched for demographics and amount of weight lost. fMRI scans (visual food motivation paradigm while hungry and following a meal) were conducted before, and 12 weeks after surgery/behavioral intervention. When compared to bariatric patients in the pre-meal analyses, behavioral dieters showed increased activation to food images in right medial PFC and left precuneus following weight loss. When compared to behavioral dieters, bariatric patients showed increased activation in in bilateral temporal cortex following the weight loss. Behavioral dieters showed increased responses to food cues in medial PFC – a region associated with valuation and processing of self-referent information – when compared to bariatric patients. Bariatric patients showed increased responses to food cues in brain regions associated with higher level perception—when compared to behavioral dieters. The method of weight loss determines unique changes in brain function.
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影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
5.7
作者：
Holsen, LM;Zarcone, JR;Savage, CR
通讯作者：
Savage, CR
影响因子：
4.8
作者：
Goebel, R;Esposito, F;Formisano, E
通讯作者：
Formisano, E
影响因子：
7.1
作者：
Le, Duc Son N. T.;Pannacciulli, Nicola;Krakoff, Jonathan
通讯作者：
Krakoff, Jonathan
影响因子：
5.1
作者：
Lalonde, L;Gray-Donald, K;Grover, SA
通讯作者：
Grover, SA