Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling.
Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling.
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DOI：
10.3389/fnbeh.2016.00203
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发表时间：
2016
影响因子：
3
通讯作者：
Schneider M
中科院分区：
文献类型：
--
作者：
Schneider P;Bindila L;Schmahl C;Bohus M;Meyer-Lindenberg A;Lutz B;Spanagel R;Schneider M
社会归属对许多物种来说至关重要，并且在青春期变得非常重要。社会归属的干扰，特别是青春期期间的社会排斥经历，会影响个人的福祉，并与精神疾病的出现有关。其潜在机制仍不清楚，部分原因是缺乏有效的动物模型。通过使用一种新型动物模型来进行社会同伴排斥，这种模型会损害青春期大鼠适当参与玩耍活动的能力，在此我们报告了社会行为的持续损害和内源性大麻素（eCB）系统的失调。从出生后第 21 天到出生后第 50 天，青春期雌性 Wistar 大鼠要么与同品系伙伴（对照）一起饲养，要么与一组 Fischer 344 大鼠（不充分的社会饲养，ISR）一起饲养，先前表明这些大鼠不能作为 Wistar 品系的不适当的游戏伙伴。成年 ISR 动物在社交互动、社交记忆、社交传播信息处理和疼痛敏感性下降方面表现出明显的缺陷。分子分析显示，在先前被同伴拒绝的大鼠中，CB1 受体 (CB1R) 蛋白水平增加，并且 CP55, 940 特别在杏仁核和丘脑中刺激 [35S]GTPγS 结合活性。随着这些变化，杏仁核中 eCB anandamide (AEA) 水平增加，其降解酶脂肪酸酰胺水解酶 (FAAH) 相应减少。我们的数据表明，青春期雌性大鼠的同伴拒绝后，会对社会行为和疼痛敏感性产生持久影响。这些行为障碍伴随着 CB1R 信号传导的持续改变。最后，我们提供了一种新颖的翻译方法来描述青春期社会同伴排斥背后的神经生物学过程。
Social affiliation is essential for many species and gains significant importance during adolescence. Disturbances in social affiliation, in particular social rejection experiences during adolescence, affect an individual’s well-being and are involved in the emergence of psychiatric disorders. The underlying mechanisms are still unknown, partly because of a lack of valid animal models. By using a novel animal model for social peer-rejection, which compromises adolescent rats in their ability to appropriately engage in playful activities, here we report on persistent impairments in social behavior and dysregulations in the endocannabinoid (eCB) system. From postnatal day (pd) 21 to pd 50 adolescent female Wistar rats were either reared with same-strain partners (control) or within a group of Fischer 344 rats (inadequate social rearing, ISR), previously shown to serve as inadequate play partners for the Wistar strain. Adult ISR animals showed pronounced deficits in social interaction, social memory, processing of socially transmitted information, and decreased pain sensitivity. Molecular analysis revealed increased CB1 receptor (CB1R) protein levels and CP55, 940 stimulated [35S]GTPγS binding activity specifically in the amygdala and thalamus in previously peer-rejected rats. Along with these changes, increased levels of the eCB anandamide (AEA) and a corresponding decrease of its degrading enzyme fatty acid amide hydrolase (FAAH) were seen in the amygdala. Our data indicate lasting consequences in social behavior and pain sensitivity following peer-rejection in adolescent female rats. These behavioral impairments are accompanied by persistent alterations in CB1R signaling. Finally, we provide a novel translational approach to characterize neurobiological processes underlying social peer-rejection in adolescence.
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影响因子：
4.7
作者：
Gordon, Ilanit;Martin, Carina;Feldman, Ruth;Leckman, James F.
通讯作者：
Leckman, James F.
影响因子：
3.3
作者：
Hill, M. N.;Tasker, J. G.
通讯作者：
Tasker, J. G.
影响因子：
3.4
作者：
Gulyas, AI;Cravatt, BF;Freund, TF
通讯作者：
Freund, TF
少年仓鼠的社交发挥改变了内侧前额叶皮层中的树突形态，并减轻了成年后社会压力的影响。
影响因子：
1.9
作者：
Burleson CA;Pedersen RW;Seddighi S;DeBusk LE;Burghardt GM;Cooper MA
通讯作者：
Cooper MA
影响因子：
4
作者：
Bernstein, Michael J.;Claypool, Heather M.
通讯作者：
Claypool, Heather M.