Reduced fractional anisotropy in projection, association, and commissural fiber networks in neonates with prenatal methamphetamine exposure.
Reduced fractional anisotropy in projection, association, and commissural fiber networks in neonates with prenatal methamphetamine exposure.
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产前接触甲基苯丙胺的新生儿的投射、关联和连合纤维网络的各向异性分数降低。
DOI：
10.1002/dneu.22784
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发表时间：
2020-11
影响因子：
3
通讯作者：
Meintjes EM
中科院分区：
文献类型：
--
作者：
Warton FL;Taylor PA;Warton CMR;Molteno CD;Wintermark P;Zöllei L;van der Kouwe AJ;Jacobson JL;Jacobson SW;Meintjes EM
Prenatal exposure to methamphetamine is associated with neurostructural changes, including alterations in white matter microstructure. This study investigated the effects of methamphetamine exposure on microstructure of global white matter networks in neonates. Pregnant women were interviewed beginning in mid-pregnancy regarding their methamphetamine use. Diffusion weighted imaging sets were acquired for 23 non-sedated neonates. White matter bundles associated with pairs of target regions within five networks (commissural fibres, left and right projection fibres, and left and right association fibres) were estimated using probabilistic tractography, and fractional anisotropy (FA) and diffusion measures determined within each connection. Multiple regression analyses showed that increasing methamphetamine exposure was significantly associated with reduced FA in all five networks, after control for potential confounders. Increased exposure was associated with lower axial diffusivity in the right association fibre network and with increased radial diffusivity in the right projection and left and right association fibre networks. Within the projection and association networks a subset of individual connections showed a negative correlation between FA and methamphetamine exposure. These findings are consistent with previous reports in older children and demonstrate that microstructural changes associated with methamphetamine exposure are already detectable in neonates.
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DOI：
10.1111/acer.13504
发表时间：
2017-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.3
作者：
Arria, Amelia M.;Derauf, Chris;Lester, Barry
通讯作者：
Lester, Barry
DOI：
10.1017/sl461145706007395
发表时间：
2007-12-01
影响因子：
4.8
作者：
Chung, Ain;Lyoo, In Kyoon;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora
影响因子：
2.6
作者：
Chaddock-Heyman, Laura;Erickson, Kirk I.;Voss, Michelle W.;Powers, John P.;Knecht, Anya M.;Pontifex, Matthew B.;Drollette, Eric S.;Moore, R. Davis;Raine, Lauren B.;Scudder, Mark R.;Hillman, Charles H.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.