The extraordinary AFD thermosensor of C. elegans.

The extraordinary AFD thermosensor of C. elegans.
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DOI:
10.1007/s00424-017-2089-5
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发表时间:
2018-05
期刊:
Pflugers Archiv : European journal of physiology
影响因子:
--
通讯作者:
Sengupta P
Sengupta P
中科院分区:
其他
文献类型:
--
作者:
Goodman MB;Sengupta P

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线虫表现出复杂的依赖于热经验的导航行为,以响应在 >10°C 的温度范围内低至 0.01°C 的环境温度变化。这种动物卓越的热感觉能力主要是通过其头部的一对 AFD 感觉神经元介导的。在这篇综述中,我们描述了 AFD 对热感觉行为和生物生理学温度依赖性调节的贡献。我们还讨论了使这种神经元类型能够适应最近的温度体验并在宽动态范围内表现出非凡的热敏感性的机制。
The nematode C. elegans exhibits complex thermal experience-dependent navigation behaviors in response to environmental temperature changes of as little as 0.01°C over a >10°C temperature range. The remarkable thermosensory abilities of this animal are mediated primarily via the single pair of AFD sensory neurons in its head. In this review, we describe the contributions of AFD to thermosensory behaviors and temperature-dependent regulation of organismal physiology. We also discuss the mechanisms that enable this neuron type to adapt to recent temperature experience and to exhibit extraordinary thermosensitivity over a wide dynamic range.
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