Functional neuroanatomy of Drosophila olfactory memory formation.
Functional neuroanatomy of Drosophila olfactory memory formation.
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DOI：
10.1101/lm.034363.114
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Davis RL
中科院分区：
文献类型：
--
作者：
Guven-Ozkan T;Davis RL
在过去的十五年中发明的新方法，技术和工具已经彻底改变了果蝇学习神经回路的功能解剖。研究人员积极地使用新方法，试图回答关于由食欲和厌恶刺激形成的嗅觉记忆的三个关键问题：（1）嗅觉神经系统中的哪些神经元介导记忆的获得？(2)从记忆获得部位延伸到控制记忆表达部位的完整神经回路是什么？(3)信息是如何在这条回路中被处理的，从而将早期形成的、可破坏的记忆巩固为稳定的、晚期的记忆？研究取得了很大进展，并得出了一些强有力的结论：（1）嗅觉神经系统内的多个部位发生了获得，但主要由γ蘑菇体神经元介导。(2)长时记忆的表达完全依赖于α/β蘑菇体神经元的突触输出。(3)巩固发生，部分，通过蘑菇体和背成对的内侧神经元之间的电路相互作用。尽管取得了这些进展，但一个完整而统一的模型，详细说明了从获得到记忆表达的途径仍然是难以捉摸的。
New approaches, techniques and tools invented over the last decade and a half have revolutionized the functional dissection of neural circuitry underlying Drosophila learning. The new methodologies have been used aggressively by researchers attempting to answer three critical questions about olfactory memories formed with appetitive and aversive reinforcers: (1) Which neurons within the olfactory nervous system mediate the acquisition of memory? (2) What is the complete neural circuitry extending from the site(s) of acquisition to the site(s) controlling memory expression? (3) How is information processed across this circuit to consolidate early-forming, disruptable memories to stable, late memories? Much progress has been made and a few strong conclusions have emerged: (1) Acquisition occurs at multiple sites within the olfactory nervous system but is mediated predominantly by the γ mushroom body neurons. (2) The expression of long-term memory is completely dependent on the synaptic output of α/β mushroom body neurons. (3) Consolidation occurs, in part, through circuit interactions between mushroom body and dorsal paired medial neurons. Despite this progress, a complete and unified model that details the pathway from acquisition to memory expression remains elusive.
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DOI：
10.1523/jneurosci.3190-10.2011
发表时间：
2011-04-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Akalal DB;Yu D;Davis RL
通讯作者：
Davis RL
影响因子：
1.9
作者：
HEISENBERG, M;BORST, A;BYERS, D
通讯作者：
BYERS, D
影响因子：
64.5
作者：
Ashraf, SI;McLoon, AL;Kunes, S
通讯作者：
Kunes, S
影响因子：
56.9
作者：
Connolly, JB;Roberts, IJH;OKane, CJ
通讯作者：
OKane, CJ
影响因子：
56.9
作者：
FEANY, MB;QUINN, WG
通讯作者：
QUINN, WG