Brain activations while processing degraded speech in adults with autism spectrum disorder
Brain activations while processing degraded speech in adults with autism spectrum disorder
复制标题
患有自闭症谱系障碍的成年人处理退化言语时的大脑激活
DOI：
10.1016/j.neuropsychologia.2021.107750
复制
发表时间：
2021
期刊：
影响因子：
2.6
通讯作者：
R.
中科院分区：
文献类型：
--
作者：
Lin;IF.;Itahashi;T.;Kashino;M.;Kato;N.;& Hashimoto;R.
患有自闭症谱系障碍（ASD）的个体被发现在不利条件下理解言语有困难。在这项研究中，我们使用噪声声码语音（VS），以调查在个人与ASD退化语音的神经处理。我们在ASD组和典型发育对照组（TDC）中进行了fMRI实验，同时他们听取了清晰语音（CS），VS和频谱旋转VS（SRVS），并要求他们注意所听到的句子并回答是否可理解。本实验中使用的VS在光谱上有所退化，但仍然可以理解，但SRVS则无法理解。我们招募了21名患有ASD的右利手成年男性和24名年龄匹配的右利手男性TDC参与者。与TDC组相比，我们观察到ASD组中左背侧运动前皮层和左颞顶交界处之间的功能连接（FC）减少，用于语音处理任务难度的影响，计算为VS-（CS + SRVS）/2。此外，观察到的FC减少与他们的自闭症谱系商数评分呈负相关。这一观察结果支持了我们的假设，即ASD患者的退化语音注意过程的背流中断可能与他们在不利条件下理解语音的困难有关。
Individuals with autism spectrum disorder (ASD) are found to have difficulties in understanding speech in adverse conditions. In this study, we used noise-vocoded speech (VS) to investigate neural processing of degraded speech in individuals with ASD. We ran fMRI experiments in the ASD group and a typically developed control (TDC) group while they listened to clear speech (CS), VS, and spectrally rotated VS (SRVS), and they were requested to pay attention to the heard sentence and answer whether it was intelligible or not. The VS used in this experiment was spectrally degraded but still intelligible, but the SRVS was unintelligible. We recruited 21 right-handed adult males with ASD and 24 age-matched and right-handed male TDC participants for this experiment. Compared with the TDC group, we observed reduced functional connectivity (FC) between the left dorsal premotor cortex and left temporoparietal junction in the ASD group for the effect of task difficulty in speech processing, computed as VS-(CS + SRVS)/2. Furthermore, the observed reduced FC was negatively correlated with their Autism-Spectrum Quotient scores. This observation supports our hypothesis that the disrupted dorsal stream for attentive process of degraded speech in individuals with ASD might be related to their difficulty in understanding speech in adverse conditions.
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DOI：
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发表时间：
--
期刊：
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影响因子：
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作者：
M. Just;T. Keller;N. Minshew;V. Cherkassky
通讯作者：
M. Just;T. Keller;N. Minshew;V. Cherkassky
影响因子：
2.5
作者：
Knaus, Tracey A.;Burns, Claire;Foundas, Anne L.
通讯作者：
Foundas, Anne L.
成人阿斯伯格综合症视听言语感知的听觉缺陷：功能磁共振成像研究
影响因子：
3.8
作者：
Fabian;L. Hundertmark;Mandy Roy;Michael J. Zerr;C. Sinke;Daniel Wiswede;M. Walter;T. Münte;G. Szycik
通讯作者：
G. Szycik
有效的连接分析表明前运动皮层在言语感知过程中的参与
影响因子：
5.7
作者：
B. Osnes;K. Hugdahl;K. Specht
通讯作者：
K. Specht
影响因子：
10.6
作者：
Redcay, Elizabeth;Courchesne, Eric
通讯作者：
Courchesne, Eric