Dual drug release electrospun core-shell nanofibers with tunable dose in the second phase.
Dual drug release electrospun core-shell nanofibers with tunable dose in the second phase.
复制标题
第二阶段剂量可调的双药物释放电纺核壳纳米纤维
DOI：
10.3390/ijms15010774
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发表时间：
2014-01-08
影响因子：
5.6
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Qian W;Yu DG;Li Y;Liao YZ;Wang X;Wang L
这项研究报告了一种新型载药核壳纳米纤维，能够在第二阶段提供可调剂量的双重控释。核壳纳米纤维是通过使用聚四氟乙烯涂层同心喷丝头的改良同轴静电纺丝制造的。分别使用聚乙烯吡咯烷酮和乙基纤维素作为壳和核聚合物基质，并编程核中活性成分对乙酰氨基酚(APAP)的含量。聚四氟乙烯涂覆的同心喷丝头可以通过改进的同轴静电纺丝技术有效、稳定地制备核壳纳米纤维，其中核流体可静电纺丝，而壳流体则不可静电纺丝。通过扫描和透射电子显微镜图像观察到，所得纳米纤维具有线性形态和清晰的核壳结构。 X 射线衍射和 FTIR 光谱测试表明，由于最喜欢的二阶相互作用，APAP 无定形分布在壳和核聚合物基质中。体外溶出测试的结果表明，核-壳纳米纤维能够提供所需的双药物控释曲线，并且在第二相中药物释放量可调。改进的同轴静电纺丝是一种有用的工具，可以生成在不同部分具有定制成分和成分的纳米结构，从而实现所需的功能性能。
This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Poly(vinyl pyrrolidone) and ethyl cellulose were used as the shell and core polymer matrices respectively, and the content of active ingredient acetaminophen (APAP) in the core was programmed. The Teflon-coated concentric spinneret may facilitate the efficacious and stable preparation of core-shell nanofibers through the modified coaxial electrospinning, where the core fluids were electrospinnable and the shell fluid had no electrospinnability. The resultant nanofibers had linear morphologies and clear core-shell structures, as observed by the scanning and transmission electron microscopic images. APAP was amorphously distributed in the shell and core polymer matrices due to the favorite second-order interactions, as indicated by the X-ray diffraction and FTIR spectroscopic tests. The results from the in vitro dissolution tests demonstrated that the core-shell nanofibers were able to furnish the desired dual drug controlled-release profiles with a tunable drug release amount in the second phase. The modified coaxial electrospinning is a useful tool to generate nanostructures with a tailored components and compositions in their different parts, and thus to realize the desired functional performances.
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