Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report.
Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report.
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DOI：
10.1186/1472-6882-10-76
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发表时间：
2010-12-09
影响因子：
--
通讯作者：
Wang JS
中科院分区：
文献类型：
--
作者：
Shen CL;Chyu MC;Pence BC;Yeh JK;Zhang Y;Felton CK;Doctolero S;Wang JS
有证据表明，绿色茶多酚（GTP）和太极（TC）运动可能有利于骨质疏松症妇女的骨骼健康。然而，其在该人群中的安全性从未进行过系统研究。特别是，存在与绿色茶提取物相关的肝毒性问题。本研究旨在评估24周GTP补充联合TC运动治疗绝经后骨质疏松妇女的安全性，沿着对该人群生活质量的影响。171名绝经后骨质减少女性被随机分配至4个治疗组，持续24周：（1）安慰剂（500 mg淀粉/天），（2）GTP（500 mg GTP/天），（3）安慰剂+ TC（安慰剂+TC训练，60分钟/次，3次/周）和（4）GTP + TC（GTP + TC训练）。通过在基线和每4周一次评估肝酶（天冬氨酸转氨酶、丙氨酸转氨酶）、碱性磷酸酶和总胆红素检查安全性。同时还评估了肾功能（尿素氮和肌酐）、钙和无机磷。在基线、12周和24周时使用SF-36问卷评价生活质量。采用重复测量ANOVA的混合模型进行分析。150例受试者完成了研究（脱落率为12%）。研究药物和TC运动的依从率分别为89%和83%。在整个研究过程中，补充GTP和TC运动均不影响肝脏或肾脏功能参数。受试者未报告研究治疗导致的不良事件。TC运动显著改善了受试者的角色-情绪和心理健康评分，而GTP补充对生活质量没有影响。在绝经后骨质疏松妇女中，每天服用500 mg GTP和/或每周3小时TC运动24周似乎是安全的，特别是在肝肾功能方面。TC运动24周（3小时/周）显着改善生活质量的角色，情绪和心理健康在这些科目。ClinicalTrials.gov标识符：NCT 00625391。
Evidence suggests that both green tea polyphenols (GTP) and Tai Chi (TC) exercise may benefit bone health in osteopenic women. However, their safety in this population has never been systematically investigated. In particular, there have been hepatotoxicity concerns related to green tea extract. This study was to evaluate the safety of 24 weeks of GTP supplementation combined with TC exercise in postmenopausal osteopenic women, along with effects on quality of life in this population. 171 postmenopausal women with osteopenia were randomly assigned to 4 treatment arms for 24 weeks: (1) Placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) Placebo + TC (placebo plus TC training at 60 min/session, 3 sessions/week), and (4) GTP + TC (GTP plus TC training). Safety was examined by assessing liver enzymes (aspartate aminotransferase, alanine aminotransferase), alkaline phosphatase, and total bilirubin at baseline and every 4 weeks. Kidney function (urea nitrogen and creatinine), calcium, and inorganic phosphorus were also assessed at the same times. Qualify of life using SF-36 questionnaire was evaluated at baseline, 12, and 24 weeks. A mixed model of repeated measures ANOVA was applied for analysis. 150 subjects completed the study (12% attrition rate). The compliance rates for study agents and TC exercise were 89% and 83%, respectively. Neither GTP supplementation nor TC exercise affected liver or kidney function parameters throughout the study. No adverse event due to study treatment was reported by the participants. TC exercise significantly improved the scores for role-emotional and mental health of subjects, while no effect on quality of life was observed due to GTP supplementation. GTP at a dose of 500 mg/day and/or TC exercise at 3 hr/week for 24 weeks appear to be safe in postmenopausal osteopenic women, particularly in terms of liver and kidney functions. TC exercise for 24 weeks (3 hr/wk) significantly improved quality of life in terms of role-emotional and mental health in these subjects. ClinicalTrials.gov identifier: NCT00625391.
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影响因子：
4.3
作者：
Qin, L;Au, S;Chan, KM
通讯作者：
Chan, KM
DOI：
10.1097/00042737-200510000-00021
发表时间：
2005-10-01
影响因子：
2.1
作者：
Gloro, R;Hourmand-Ollivier, I;Dao, T
通讯作者：
Dao, T
影响因子：
6.3
作者：
Hsu, Chung-Hua;Tsai, Tung-Hu;Chou, Pesus
通讯作者：
Chou, Pesus
影响因子：
7.7
作者：
Tanaka, K;Tokunaga, S;Zakouji, H
通讯作者：
Zakouji, H
影响因子：
10.6
作者：
Rayman, M;Thompson, A;Bliss, J
通讯作者：
Bliss, J