COVID-19 in lung transplant recipients: A multicenter study.
COVID-19 in lung transplant recipients: A multicenter study.
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DOI：
10.1111/ajt.16364
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发表时间：
2021-05
期刊：
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本研究描述了肺移植受者（LTR）中SARS-CoV-2感染的临床表现、治疗和结局。这是一项多中心、回顾性研究，研究对象为2020年3月4日至4月28日期间在西班牙6家肺移植参考医院确诊为SARS-CoV-2感染的所有成人LTR。临床和放射学数据，治疗特点，结果进行了审查。在此期间查明了44起案件。移植后中位时间为4.2年（四分位距：1.11-7.3）。胸部X线检查显示急性肺实质异常32例（73%）。41例（93%）患者使用羟氯喹，14例（32%）患者使用洛匹那韦/利托那韦（LPV/r），19例（43%）患者使用托珠单抗。在所有病例中，他克莫司和LPV/r之间存在强烈的相互作用。37例（84%）患者需要一定程度的呼吸支持和/或氧气治疗，13例（30%）患者入住中级或重症监护室。在末次随访时，17例（39%）患者死亡，20例（45%）患者出院。死亡患者入院时呼吸状态和胸部X线检查较差，D-二聚体、白细胞介素-6和乳酸脱氢酶水平较高。在该多中心LTR队列中，SARS-CoV-2的死亡率较高。此外，发病时疾病的严重程度可预测随后的死亡率。
This study describes the clinical presentation, treatment, and outcomes of SARS-CoV-2 infection in lung transplant recipients (LTRs). This is a multicenter, retrospective study of all adult LTRs with confirmed SARS-CoV-2 infection from March 4 until April 28, 2020 in six Spanish reference hospitals for lung transplantation. Clinical and radiological data, treatment characteristics, and outcomes were reviewed. Forty-four cases were identified in that period. The median time from transplantation was 4.2 (interquartile range: 1.11–7.3) years. Chest radiography showed acute parenchymal abnormalities in 32 (73%) cases. Hydroxychloroquine was prescribed in 41 (93%), lopinavir/ritonavir (LPV/r) in 14 (32%), and tocilizumab in 19 (43%) patients. There was a strong interaction between tacrolimus and LPV/r in all cases. Thirty-seven (84%) patients required some degree of respiratory support and/or oxygen therapy, and 13 (30%) were admitted to intermediate or intensive critical care units. Seventeen (39%) patients had died and 20 (45%) had been discharged at the time of the last follow-up. Deceased patients had a worse respiratory status and chest X-ray on admission and presented with higher D-dimer, interleukin-6, and lactate dehydrogenase levels. In this multicenter LTR cohort, SARS-CoV-2 presented with high mortality. Additionally, the severity of disease on presentation predicted subsequent mortality.
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DOI：
10.1111/ajt.15896
发表时间：
2020-07
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
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通讯作者：
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影响因子：
23.4
作者：
Zhang, Hui;Chen, Yan;Wang, Zhen-Di
通讯作者：
Wang, Zhen-Di
影响因子：
8.8
作者：
Zhu, Lan;Xu, Xizhen;Chen, Gang
通讯作者：
Chen, Gang
影响因子：
8.8
作者：
Verleden, Geert M.;Godinas, Laurent;Vos, Robin
通讯作者：
Vos, Robin
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
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作者：
Richardson, Safiya;Hirsch, Jamie S.;,
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