Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis.
Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis.
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室内晒黑和非黑色素瘤皮肤癌：系统评价和荟萃分析。
DOI：
10.1136/bmj.e5909
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发表时间：
2012-10-02
期刊：
影响因子：
--
通讯作者：
Linos E
中科院分区：
文献类型：
--
作者：
Wehner MR;Shive ML;Chren MM;Han J;Qureshi AA;Linos E
目的 综合有关室内晒黑和非黑色素瘤皮肤癌的文献。设计系统回顾和荟萃分析。数据来源 PubMed（1966 年至今）、Embase（1974 年至今）和 Web of Science（1898 年至今）。研究选择 所有报告室内晒黑和非黑色素瘤皮肤癌原始效果统计数据的文章都包括在内。不提供任何数据的文章（例如评论文章和社论）以及英语以外语言的文章均被排除在外。数据提取 两名研究者独立提取数据。使用随机效应荟萃分析来总结曾经使用过与从未使用过室内晒黑的相对风险。还检查了剂量反应效应和生命早期接触室内晒黑的情况。计算了美国人口的人口归因风险分数。结果纳入了 12 项研究，涉及 9328 例非黑色素瘤皮肤癌病例。与从未使用过室内晒黑的人相比，曾经使用过室内晒黑的人患鳞状细胞癌的总体相对风险为 1.67（95% 置信区间为 1.29 至 2.17），基底细胞癌的总体相对风险为 1.29（1.08 至 1.53）。研究之间不存在显着的异质性。美国鳞状细胞癌的人群归因风险分数估计为 8.2%，基底细胞癌的人群归因风险分数为 3.7%。这相当于每年有超过 170 万例非黑色素瘤皮肤癌归因于室内晒黑。根据三项研究的数据，25 岁之前进行室内晒黑与鳞状细胞癌（相对风险 2.02、0.70 至 5.86）和基底细胞癌（相对风险 1.40、1.29 至 1.52）的相关性更强。结论 室内晒黑与基底细胞和鳞状细胞皮肤癌的风险显着增加相关。早年（<25 岁）使用的风险更高。这种可改变的危险因素可能导致每年仅在美国以及全世界更多的非黑色素瘤皮肤癌病例。这些发现为越来越多的关于室内晒黑危害的证据提供了证据，并支持公共卫生运动和监管以减少接触这种致癌物。
Objective To synthesise the literature on indoor tanning and non-melanoma skin cancer. Design Systematic review and meta-analysis. Data sources PubMed (1966 to present), Embase (1974 to present), and Web of Science (1898 to present). Study selection All articles that reported an original effect statistic for indoor tanning and non-melanoma skin cancer were included. Articles that presented no data, such as review articles and editorials, were excluded, as were articles in languages other than English. Data extraction Two investigators independently extracted data. Random effects meta-analysis was used to summarise the relative risk of ever use versus never use of indoor tanning. Dose-response effects and exposure to indoor tanning during early life were also examined. The population attributable risk fraction for the United States population was calculated. Results 12 studies with 9328 cases of non-melanoma skin cancer were included. Among people who reported ever using indoor tanning compared with those who never used indoor tanning, the summary relative risk for squamous cell carcinoma was 1.67 (95% confidence interval 1.29 to 2.17) and that for basal cell carcinoma was 1.29 (1.08 to 1.53). No significant heterogeneity existed between studies. The population attributable risk fraction for the United States was estimated to be 8.2% for squamous cell carcinoma and 3.7% for basal cell carcinoma. This corresponds to more than 170 000 cases of non-melanoma skin cancer each year attributable to indoor tanning. On the basis of data from three studies, use of indoor tanning before age 25 was more strongly associated with both squamous cell carcinoma (relative risk 2.02, 0.70 to 5.86) and basal cell carcinoma (1.40, 1.29 to 1.52). Conclusions Indoor tanning is associated with a significantly increased risk of both basal and squamous cell skin cancer. The risk is higher with use in early life (<25 years). This modifiable risk factor may account for hundreds of thousands of cases of non-melanoma skin cancer each year in the United States alone and many more worldwide. These findings contribute to the growing body of evidence on the harms of indoor tanning and support public health campaigns and regulation to reduce exposure to this carcinogen.
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影响因子：
10.3
作者：
HOGAN, DJ;TO, T;LANE, P
通讯作者：
LANE, P
DOI：
10.1080/01635581.2011.523496
发表时间：
2011
期刊：
Nutrition and cancer
影响因子：
--
作者：
Asgari MM;White E;Warton EM;Hararah MK;Friedman GD;Chren MM
通讯作者：
Chren MM
影响因子：
120.7
作者：
Christenson, LJ;Borrowman, TA;Roenigk, RK
通讯作者：
Roenigk, RK
影响因子：
8.4
作者：
Boldeman, C;Bränström, R;Ullén, H
通讯作者：
Ullén, H
DOI：
10.1111/j.1753-6405.2010.00578.x
发表时间：
2010-08-01
影响因子：
3.5
作者：
Francis, Kate;Dobbinson, Suzanne;Girgis, Afaf
通讯作者：
Girgis, Afaf