Effects of Genetic Recombination and Population Subdivision on Nucleotide Sequence Variation in Drosophila ananassae

Effects of Genetic Recombination and Population Subdivision on Nucleotide Sequence Variation in Drosophila ananassae
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遗传重组和群体细分对果蝇核苷酸序列变异的影响

DOI:
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发表时间:
1994
期刊:
影响因子:
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通讯作者:
W. Stephan
W. Stephan
中科院分区:
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文献类型:
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作者:
W. Stephan

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在DNA序列水平上定量分析了缅甸和印度两个天然果蝇种群高重组率和低重组率区域的遗传变异。这些种群之间的基因流动是有限的。每物理长度低交叉区域的DNA序列变异水平显著低于中高交叉区域。此外,在低交叉区域发现了固定的种群间差异,而在高交叉区域则没有。在后一种情况下,种群间多态性的频率变化更为缓慢。与搭便车有关的简单的方向选择模型只能部分地解释这些观察结果。为了解释限制性重组区域的快速遗传分化,必须假定局部适应性扫描。
Genetic variation in regions of high and low recombination rates was quantified at the DNA sequence level for two natural Drosophila ananassae populations from Myanmar and India. Gene flow between these populations is limited. Levels of DNA sequence variation in regions of low crossing-over per physical length are significantly lower than in regions of intermediate to high crossing-over. Furthermore fixed between-population differences were found in low crossing-over regions but not in regions of high crossing-over. In the latter ones frequency shifts in polymorphisms between populations are more gradual. Simple models of directional selection in conjunction with hitchhiking explain these observations only partially. Local adaptive sweeps have to be postulated to account for the rapid genetic differentiation in regions of restricted recombination.
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