Photosensitivity in cutaneous lupus erythematosus.

Photosensitivity in cutaneous lupus erythematosus.
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DOI:
10.1111/phpp.12018
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发表时间:
2013-02
期刊:
Photodermatology, photoimmunology & photomedicine
影响因子:
--
通讯作者:
Chong BF
Chong BF
中科院分区:
其他
文献类型:
--
作者:
Kim A;Chong BF

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皮肤红斑狼疮(CLE)包括几种不同的形式,包括急性,亚急性和慢性表现,可能会或可能不会发生在系统性红斑狼疮(SLE)的设置。紫外线辐射(UVR)是CLE的众所周知的恶化因素,其中光敏性包括SLE的美国流变学学会(ACR)诊断标准之一。然而,由于ACR使用的广泛语言和光敏性狼疮病变的延迟发作性质,在该人群中辨别真正的光敏性是困难的。光激发试验提供了一种更客观的方法来测量光敏性,但光激发试验表明,由于协议的变化显着不同的结果。尽管UVR对狼疮患者有有害作用,但UVA-1可能具有治疗益处,如对小鼠和人类狼疮受试者的一些观察所示。准确识别光敏性对SLE具有诊断意义,并为患者更好地坚持光保护措施提供动力。
Cutaneous lupus erythematosus (CLE) encompasses several different forms including acute, subacute, and chronic manifestations that may or may not occur in the setting of systemic lupus erythematosus (SLE). Ultraviolet radiation (UVR) is a well-known exacerbating factor for CLE, with photosensitivity comprising one of the American College of Rheumatology (ACR) diagnostic criteria for SLE. However, discerning true photosensitivity in this population is difficult due to the broad language utilized by the ACR and the delayed-onset nature of photosensitive lupus lesions. Photoprovocation testing provides a more objective method to measure photosensitivity, but photoprovocation trials demonstrate significantly varying results due to protocol variations. Despite UVR’s deleterious effect on lupus patients, UVA-1 may have therapeutic benefits as shown by some observations on murine and human lupus subjects. Accurately discerning photosensitivity has diagnostic implications for SLE and provides motivation for greater patient adherence to photoprotective measures.
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