Peripheral tissue homing receptor control of naïve, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues.
Peripheral tissue homing receptor control of naïve, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues.
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DOI：
10.3389/fimmu.2013.00241
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发表时间：
2013
影响因子：
7.3
通讯作者：
Engelhard VH
中科院分区：
文献类型：
--
作者：
Brinkman CC;Peske JD;Engelhard VH
T细胞激活诱导结合外周组织脉管配体的归巢受体，编程运动到感染和损伤部位。基于归巢受体表达的CD8效应T细胞主要有三种类型，它们出现在不同的淋巴器官中。最近的出版物表明naïve，效应和记忆T细胞迁移比以前认为的更复杂；当许多效应器进入外周组织时，一些效应器重新进入淋巴结（LN），并含有中枢记忆前体。LN再入可依赖CD62L或外周组织归巢受体。LN中的记忆T细胞倾向于表达与其祖先相同的归巢受体，但通常是CD62Lneg。归巢受体也控制CD8 T细胞进入肿瘤。肿瘤血管有许多低水平的外周组织归巢受体配体，但其部分类似于高内皮小静脉（HEV），使naïve T细胞进入、激活和随后的效应活性。这种血管系统与人类的积极预后有关，表明它可能维持持续的抗肿瘤反应。这些发现揭示了naïve、效应和记忆CD8 T细胞表达的归巢受体在控制进入淋巴和非淋巴组织中的新作用。
T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programing movement to sites of infection and injury. There are three major types of CD8 effector T cells based on homing receptor expression, which arise in distinct lymphoid organs. Recent publications indicate that naïve, effector, and memory T cell migration is more complex than once thought; while many effectors enter peripheral tissues, some re-enter lymph nodes (LN), and contain central memory precursors. LN re-entry can depend on CD62L or peripheral tissue homing receptors. Memory T cells in LN tend to express the same homing receptors as their forebears, but often are CD62Lneg. Homing receptors also control CD8 T cell tumor entry. Tumor vasculature has low levels of many peripheral tissue homing receptor ligands, but portions of it resemble high endothelial venules (HEV), enabling naïve T cell entry, activation, and subsequent effector activity. This vasculature is associated with positive prognoses in humans, suggesting it may sustain ongoing anti-tumor responses. These findings reveal new roles for homing receptors expressed by naïve, effector, and memory CD8 T cells in controlling entry into lymphoid and non-lymphoid tissues.
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DOI：
10.4049/jimmunol.181.3.1814
发表时间：
2008-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brinkman CC;Sheasley-O'Neill SL;Ferguson AR;Engelhard VH
通讯作者：
Engelhard VH
影响因子：
5.2
作者：
Bergomas F;Grizzi F;Doni A;Pesce S;Laghi L;Allavena P;Mantovani A;Marchesi F
通讯作者：
Marchesi F
DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
异位LT Alphaββ指导淋巴器官新生成，并具有外周节点地址和HEV限制的磺胺转移酶的表达。
DOI：
10.1084/jem.20021761
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Drayton DL;Ying X;Lee J;Lesslauer W;Ruddle NH
通讯作者：
Ruddle NH
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ