Functionalized gold nanorods for nanomedicine: Past, present and future

Functionalized gold nanorods for nanomedicine: Past, present and future
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用于纳米医学的功能化金纳米棒:过去、现在和未来

DOI:
10.1016/j.ccr.2017.08.020
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发表时间:
2017-12
期刊:
《Coordination Chemistry Reviews》 , 2017 , 352 :15-66
影响因子:
--
通讯作者:
Ken-Tye Yong
Ken-Tye Yong
中科院分区:
其他
文献类型:
--
作者:
Jie Zhou;Zhonglin Cao;Nishtha Panwar;Rui Hu;Xiaomei Wang;Junle Qu;Swee Chuan Tjin;Gaixia Xu;Ken-Tye Yong

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金纳米棒(GNR)因其极具吸引力的光学特性及其在生物传感和纳米医学领域的各种应用而一直处于生物光子学的前沿。在这篇综述中,我们首先介绍了 GNR 的合成和功能化方法,然后描述了 GNR 非凡的光学特性。此后,我们详细阐述了使用 GNR 进行传感的最新研究进展,并重点介绍了 GNR 在体外和体内诊断和治疗应用中的日益增长的使用。我们还讨论了 GNR 对身体和环境的毒性影响,并对表面修饰在影响生物系统毒性方面的作用进行了评估。最后,我们对 GNR 在研究和临床应用中的总体现状、挑战和未来方向提供了总结性观点。
Gold nanorods (GNRs) have been on the forefront in biophotonics due to their extremely attractive optical properties and their use in a variety of applications in biosensing and nanomedicine. In this review, we first present the synthesis and functionalization approaches and then describe the extraordinary optical properties of GNRs. Thereafter, we elaborate on the recent research advances in the use of GNRs for sensing, and highlight the increasing use of GNRs forin vitroandin vivodiagnostics and therapeutic applications. We also discuss the toxicity effects of GNRs on the body and environment and present an evaluation on the role of surface modifications in affecting the toxicity in biological systems. Finally, we provide concluding perspectives on the overall current status, challenges, and future directions for the use of GNRs in research and clinical applications.
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