Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community.
Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community.
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DOI：
10.1289/ehp.7894
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发表时间：
2005-12
影响因子：
10.4
通讯作者：
McKone TE
中科院分区：
文献类型：
--
作者：
Bradman A;Eskenazi B;Barr DB;Bravo R;Castorina R;Chevrier J;Kogut K;Harnly ME;McKone TE
关于孕妇接触农药的信息很少。我们测量了600名生活在加州萨利纳斯山谷农业区的低收入孕妇尿液中有机磷农药的六种二烷基磷酸（DAP）代谢物。共有28%的妇女在怀孕期间受雇为农场工作人员，81%的妇女至少有一名家庭成员从事农业工作。在妊娠期间（平均为13周和26周）和分娩后（平均为9天）采集两次样本。与其他研究一样，二甲基二硫代磷酸盐水平高于其他尿OP代谢物。分娩后收集的样本中总DAP代谢物水平高于妊娠期间收集的样本。产前第一次和第二次采样点以及产后采集时的代谢物水平中位数分别为102.8、106.8和227.2 nmol/L。这些萨利纳斯山谷妇女的产前和产后代谢物水平都高于美国一般人口的育龄妇女样本（国家健康和营养检查调查），尽管在分娩后与美国参考水平的偏差最为明显。产后期间较高的DAP代谢物水平可能对怀孕期间的剂量估计和哺乳期间的暴露有影响。
Little information has been published about pesticide exposures experienced by pregnant women. We measured six dialkyl phosphate (DAP) urinary metabolites of organophosphate (OP) pesticides in 600 pregnant, low-income women living in the Salinas Valley, California, an agricultural area. A total of 28% were employed as farm fieldworkers during pregnancy, and 81% had at least one household member who worked in agriculture. Samples were collected twice during pregnancy (mean = 13 and 26 weeks’ gestation, respectively) and just after delivery (mean = 9 days). As in other studies, dimethyldithiophosphate levels were higher than those of other urinary OP metabolites. Total DAP metabolite levels in samples collected after delivery were higher than in samples collected during pregnancy. Median metabolite levels at the first and second prenatal sampling points and at the postpartum collection were 102.8, 106.8, and 227.2 nmol/L, respectively. Both prenatal and postpartum metabolite levels were higher in these Salinas Valley women than in a sample of women of childbearing age in the general U.S. population (National Health and Nutrition Examination Survey), although the deviation from U.S. reference levels was most pronounced after delivery. Higher DAP metabolite levels in the immediate postpartum period may have implications for estimating dose during pregnancy and for exposure during lactation.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
10.4
作者：
Needham LL
通讯作者：
Needham LL
在多种族的城市队列中，怀孕期间室内农药接触。
影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
影响因子：
2.5
作者：
Bravo, R;Driskell, WJ;Barr, DB
通讯作者：
Barr, DB
DOI：
10.1111/j.1471-0528.1981.tb00930.x
发表时间：
1981-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
DAVISON, JM;NOBLE, MCB
通讯作者：
NOBLE, MCB