Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes.

Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes.
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DOI:
10.1289/ehp.7490
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发表时间:
2005-04
影响因子:
10.4
通讯作者:
Needham LL
Needham LL
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Needham LL

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对于评估可能接触环境化学品与不良后果之间关系的流行病学研究,需要对接触和健康后果进行准确评估。三个前瞻性队列研究最近评估了通过生物监测评估的孕妇接触有机磷农药与几种分娩结局之间的关系。这三个研究在暴露情景和暴露评估方面进行了比较。主要的重点是暴露评估,所有这些评估都采用生物监测,但使用不同的方法,这可能导致不同的发现。这些方法和他们如何可能有助于不同关系之间的暴露和分娩结果进行了审查。
For epidemiologic studies that evaluate the relation between potential exposures to environmental chemicals and adverse outcomes, accurate assessments of exposures and health outcomes are needed. Three prospective cohort studies recently evaluated the relation between exposure, as assessed by biomonitoring, of pregnant women to organophosphorus pesticides and several birth outcomes. Here these three studies are compared in terms of the exposure scenarios and exposure assessments. The primary focus is on the exposure assessments, all of which employ biomonitoring but use different approaches, which may contribute to the different findings. These approaches and how they may contribute to different relations between exposure and birth outcomes are examined.
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