Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli.
Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli.
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DOI：
10.1111/acer.14744
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Schuckit MA
中科院分区：
文献类型：
--
作者：
McKenna BS;Anthenelli RM;Smith TL;Schuckit MA
对酒精的低水平反应（低LR）预示着大量饮酒和酒精问题。情感处理的功能性磁共振成像（fMRI）研究表明，低LR个体在安慰剂和酒精给药后，任务相关脑区的激活程度较低，但这些研究没有检查可能导致这种现象的功能性脑网络。目前的研究扩展了这些早期的结果，通过评估杏仁核和其他大脑区域之间的功能连接差异是否同样与LR相关。在前人研究的基础上，我们推测低LR可能与额杏仁核功能回路中较低的功能连接有关。对108对基线时无酒精使用障碍的18-25岁低LR和高LR性别匹配配对的双盲、安慰剂对照、受试者内交叉研究的数据进行次要分析。受试者在服用安慰剂或大约0.7 mL/kg乙醇后进行改良的情绪面孔处理任务。心理生理学的相互作用分析研究功能之间的连接左，右杏仁核和相关的大脑回路使用LR酒精一般线性模型。数据包括54对性别匹配的216次fMRI扫描，包括酒精和安慰剂条件。与高LR的个体相比，低LR的受试者在处理愤怒和快乐的面孔时，杏仁核与额叶、颞叶和顶叶区域之间的功能连接性较低。相互作用表现出较低的连接后，酒精在低LR和高LR组的连接。低LR个体表现出较低的功能连接与安慰剂和响应于适度的乙醇剂量。低LR个体在处理情绪面孔时的连接减弱可能导致识别社交场合中酒精中毒的能力受损，以及对愤怒和快乐情绪进行评估的能力受损，而不管是否饮酒。
Low levels of response (low LR) to alcohol predict heavy drinking and alcohol problems. Functional magnetic resonance imaging (fMRI) studies of emotion processing have demonstrated low LR individuals exhibit lower activation in task-related brain regions following both placebo and alcohol administration but the studies did not examine functional brain networks that might contribute to the phenomena. The current study expands upon those earlier results by evaluating if functional connectivity differences between the amygdala and other brain regions modulated by emotional face processing are likewise associated with LR. Based on the prior study, we hypothesized that low LR will be related to lower functional connectivity in fronto-amygdalar functional circuits underlying processing of emotional stimuli. Secondary analyses were conducted on data from a double-blind, placebo controlled, within-subjects, cross-over study in 108 18-to-25-year-old low and high LR sex matched pairs without an alcohol use disorder at baseline. Participants performed modified emotional faces processing tasks after placebo or approximately 0.7 mL/kg of ethanol. Psychophysiological interaction analyses examined functional connectivity between left and right amygdala and related brain circuits using LR-by-alcohol general linear models. The data included 54 sex-matched pairs with 216 fMRI scans comprising alcohol and placebo conditions. Compared with individuals with high LR, low LR subjects demonstrated lower functional connectivity between the amygdala and the frontal lobes, insula, and parietal regions, respectively, while processing angry and happy faces. Interactions showed lower connectivity following alcohol in low LR and higher connectivity in high LR groups. Low LR individuals demonstrated lower functional connectivity both with placebo and in response to a modest ethanol dose. Attenuated connectivity among low LR individuals when processing emotional faces may contribute to an impaired ability to recognize alcohol intoxication in social situations and impaired ability to make appraisals of angry and happy emotions irrespective of consuming alcohol.
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影响因子：
5.7
作者：
Alarcón G;Cservenka A;Rudolph MD;Fair DA;Nagel BJ
通讯作者：
Nagel BJ
影响因子：
5.3
作者：
Gilman, Jodi M.;Ramchandani, Vijay A.;Hommer, Daniel W.
通讯作者：
Hommer, Daniel W.
影响因子：
5.7
作者：
Hariri, AR;Tessitore, A;Weinberger, DR
通讯作者：
Weinberger, DR
DOI：
10.15288/jsa.2001.62.562
发表时间：
2001-09-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Ehlers, CL;Wall, TL;Phillips, E
通讯作者：
Phillips, E
DOI：
10.1111/j.1530-0277.2007.00535.x
发表时间：
2007-12-01
影响因子：
3.2
作者：
Hill, Shirley Y.;Kostelnik, Bryan;Keshavan, Matcheri
通讯作者：
Keshavan, Matcheri