Transformation of Black Phosphorus through Lattice Reconstruction for NIR-II-Responsive Cancer Therapy.
Transformation of Black Phosphorus through Lattice Reconstruction for NIR-II-Responsive Cancer Therapy.
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DOI：
10.1002/advs.202305762
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发表时间：
2024-01
期刊：
影响因子：
15.1
通讯作者：
Yu, Xue-Feng
中科院分区：
文献类型：
--
作者：
Wu, Lie;Jiang, Mingyang;Chu, Chenchen;Luo, Tingting;Hui, Yun;Zhou, Wenhua;Geng, Shengyong;Yu, Xue-Feng
黑磷（BP）在近红外（NIR）-II生物窗口（1000-1500 nm）的光热性能较低，限制了其生物医学应用。本文以BP量子点（BPQDs）为模板，通过拓扑化学转化合成了超小型磷化镍量子点（Ni2P QDs）。 Ni2P QD 的尺寸约为 3.5 nm，与 BPQD 相似，而 Ni2P QD 在 1064 nm 处的吸收和光热转换效率（43.5%）较 BPQD 显着提高。为了促进体内应用，通过将 Ni2P QD 和阿霉素 (DOX) 分别掺入脂质体双层和内部，设计了基于 Ni2P QD 的脂质体纳米平台 (Ni2P-DOX@Lipo-cRGD)。由于Ni2P量子点的光热效应，封装的DOX在1064 nm激光照射下从脂质体中响应释放，并且药物释放速率和量由光强度和曝光时间控制。体内实验表明，Ni2P-DOX@Lipo-cRGD具有优异的肿瘤靶向能力和生物相容性，能够通过光热疗法和化疗相结合来彻底消融肿瘤。这项工作为纳米材料的 NIR-II 转化提供了新的范例，并可能为构建用于癌症治疗的多功能纳米平台提供线索。通过晶格重建将NIR-I响应的黑磷量子点拓扑化学转化为NIR-II响应的磷化镍量子点（Ni2P QD），并将其嵌入脂质体双层中以构建抗癌纳米平台（Ni2P-DOX@Lipo-cRGD）。 Ni2P-DOX@Lipo-cRGD 实现了靶向递送、按需药物释放和完全肿瘤消融。
The photothermal performance of black phosphorus (BP) in the near infrared (NIR)‐II bio‐window (1000–1500 nm) is low, which limits its biomedical applications. Herein, ultrasmall nickel phosphide quantum dots (Ni2P QDs) are synthesized with BP quantum dots (BPQDs) as the template by topochemical transformation. The size of Ni2P QDs is ≈3.5 nm, similar to that of BPQDs, whereas the absorption and photothermal conversion efficiency of Ni2P QDs at 1064 nm (43.5%) are significantly improved compared with those of BPQDs. To facilitate in vivo applications, an Ni2P QDs‐based liposomal nano‐platform (Ni2P‐DOX@Lipo‐cRGD) is designed by incorporation of Ni2P QDs and doxorubicin (DOX) into liposomal bilayers and the interior, respectively. The encapsulated DOX is responsively released from liposomes upon 1064‐nm laser irradiation owing to the photothermal effect of Ni2P QDs, and the drug release rate and amount are controlled by the light intensity and exposure time. In vivo, experiments show that Ni2P‐DOX@Lipo‐cRGD has excellent tumor target capability and biocompatibility, as well as complete tumor ablation through the combination of photothermal therapy and chemotherapy. The work provides a new paradigm for the NIR‐II transformation of nano‐materials and may shed light on the construction of multifunctional nano‐platforms for cancer treatment. NIR‐I‐responsive black phosphorus quantum dots are topochemically transformed to NIR‐II‐responsive nickel phosphide quantum dots (Ni2P QDs) through lattice reconstruction, which are embedded into liposomal bilayers to construct an anti‐cancer nanoplatform (Ni2P‐DOX@Lipo‐cRGD). Targeted delivery, on‐demand drug release, and complete tumor ablation are realized by Ni2P‐DOX@Lipo‐cRGD.
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