Disentangling between- and within-person alcohol and expectancy effects on acute alcohol craving.
Disentangling between- and within-person alcohol and expectancy effects on acute alcohol craving.
复制标题
DOI：
10.1007/s00213-023-06372-0
复制
发表时间：
2023-06
影响因子：
3.4
通讯作者：
Corbin, William R.
中科院分区：
文献类型：
--
作者：
Waddell, Jack T.;King, Scott E.;Corbin, William R.
酒精渴望是持续饮酒的预测因子，也是酒精使用障碍的诊断标准。奖励的主观效应会增强渴望，但目前尚不清楚这种关系是由期望驱动的还是由酒精引起的。此外，尚不清楚这种关系是否仅在个人层面上运作，或者是否也存在个人内部的动态变化。参与者（N = 448）来自一项安慰剂控制的酒精管理研究。酒精条件下的参与者报告了对上升（BAC = 0.068）、峰值（BAC = 0.079）和下降（BAC = 0.066） BAC肢体的主观影响和酒精渴望。安慰剂组的参与者与酒精组的参与者被捆绑在一起。多水平模型检验了(1)主观效应的人内偏差是否预测了渴望的人内偏差，(2)主观效应的人间水平是否预测了渴望的人间水平，以及(3)效应是否依赖于实验条件。在个人水平上，无论实验条件如何，高觉醒积极/刺激效应的增加与个人对酒精渴望的增加有关。在人际层面上，观察到高唤醒的积极/兴奋（和低唤醒的积极/放松）效应与条件之间的相互作用。探索表明，在酒精组中，个人水平的高唤醒、积极/兴奋效应与渴望之间的关联在统计上是显著的，而在安慰剂组中则没有。相反，个人水平的低唤醒、积极/放松效应与渴望之间的关联在安慰剂组呈正相关，在统计上显著，但在酒精组呈负相关。研究结果表明，高唤醒的积极/刺激效应与人的渴望之间存在类似期望的关系。然而，酒精引起的正强化（即刺激）促进了个人层面的渴望，而类似期望的负强化（即放松）则减弱了个人层面的渴望。
Alcohol craving is a predictor of continued drinking and a diagnostic criterion for alcohol use disorder. Rewarding subjective effects potentiate craving, but it remains unclear if relations are expectancy-driven vs. alcohol-induced. In addition, it remains unclear if relations operate solely at the person level, or if there is also within-person dynamic change. Participants (N = 448) come from a placebo-controlled alcohol administration study. Participants in the alcohol condition reported subjective effects and alcohol craving on ascending (BAC = .068), peak (BAC = .079), and descending (BAC = .066) BAC limbs. Participants in the placebo condition were yoked to alcohol condition participants. Multilevel models tested whether (1) within-person deviations in subjective effects predicted within-person deviations in craving, (2) between-person levels of subjective effects predicted between-person levels of craving, and (3) effects were dependent upon experimental condition. At the within-person level, increases in high arousal positive/stimulant effects were associated with within-person increases in alcohol craving, regardless of experimental condition. At the between-person level, interactions were observed between high arousal positive/stimulant (and low arousal positive/relaxing) effects and condition. Probing suggested that the association between person-level high arousal positive/stimulant effects and craving was statistically significant in the alcohol but not the placebo condition. Conversely, the association between person-level low arousal positive/relaxing effects and craving was positive and statistically significant in the placebo but negative in the alcohol condition. Findings suggest expectancy-like relations among high arousal positive/stimulant effects and craving within-person. However, alcohol-induced positive reinforcement (i.e., stimulation) facilitated heightened person-level craving, whereas expectancy-like negative reinforcement (i.e., relaxation) attenuated person-level craving.
登录
查看更多内容
影响因子：
2.3
作者：
Waddell, Jack T.;Corbin, William R.;Chassin, Laurie;Anderson, Samantha F.
通讯作者：
Anderson, Samantha F.
影响因子：
2.3
作者：
Corbin WR;Hartman JD;Bruening AB;Fromme K
通讯作者：
Fromme K
影响因子：
4.2
作者：
Grant, BF;Dawson, DA;Pickering, R
通讯作者：
Pickering, R
影响因子：
2.3
作者：
King，Scott E.;Waddell，Jack T.;Corbin，William R.
通讯作者：
Corbin，William R.
影响因子：
3.4
作者：
Berey, Benjamin L.;Leeman, Robert F.;King, Andrea C.
通讯作者：
King, Andrea C.