Distance to pig farms as risk factor for community-onset livestock-associated MRSA CC398 infection in persons without known contact to pig farms-A nationwide study.
Distance to pig farms as risk factor for community-onset livestock-associated MRSA CC398 infection in persons without known contact to pig farms-A nationwide study.
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DOI：
10.1111/zph.12441
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发表时间：
2018-05
影响因子：
2.4
通讯作者：
Jepsen MR
中科院分区：
文献类型：
--
作者：
Anker JCH;Koch A;Ethelberg S;Mølbak K;Larsen J;Jepsen MR
MRSA CC398是一种新出现的MRSA菌株，在牲畜中发现，主要在猪中发现。直接接触家畜是人类感染MRSA CC398的主要危险因素。然而，近年来，在没有已知的猪接触者中观察到越来越多的MRSA CC398病例。这类病例被称为来源不明的MRSA CC398(MUO CC398)，与家畜发病(LO)MRSA CC398病例一样，已发现集中在农村畜牧业地区。MUO CC398病例的存在表明有其他未知的MRSA CC398传播途径进入社区。我们在丹麦进行了一项全国性的研究，以丹麦人口为背景，研究了一般MRSA病例和MUO CC398或Lo MRSA CC398感染者的地理分布(2006年1月1日至2015年2月11日)。使用ArcGIS软件绘制研究对象的居住地地图，并从中央畜牧业登记册检索关于养猪场的信息。MUO CC398感染在农村地区的发病率明显高于城市地区，这些病例平均居住在离养猪场更近的地方，而不是普通人群。然而，在养猪业密集的三个城市中，MUO CC398感染患者的居住地点并不比人口控制区域离养猪场更近。这表明，从邻近的MRSA CC398养猪场直接向环境传播的可能性不大。相反，通过其他传播途径而不是从农场直接传播的社区传播更可能解释MUO CC398在牲畜密集地区聚集的原因。
MRSA CC398 is an emerging MRSA strain found in livestock, mainly in pigs. Direct occupational livestock contact is the principal risk factor for human MRSA CC398 infection. Nonetheless, in recent years, an increasing number of MRSA CC398 cases has been observed in persons without known pig contact. Such cases, referred to as MRSA CC398 of unknown origin (MUO CC398), have, like livestock-onset (LO) MRSA CC398 cases, been found concentrated in rural, livestock-producing areas. The presence of MUO CC398 cases indicates alternative and unknown MRSA CC398 transmission pathways into the community. We performed a nationwide study in Denmark of the geographic distributions of MRSA cases in general and persons with MUO CC398 or LO MRSA CC398 infections (1 January 2006–11 February 2015), with the Danish population as background population. Place of living of study persons was mapped using the ArcGIS software, and information on pig farms was retrieved from the Central Husbandry Register. The incidence of MUO CC398 infections was clearly higher in rural than in urban areas, and such cases lived on average closer to pig farms than the general population. However, within three pig-farming-dense municipalities, patients with MUO CC398 infections did not live closer to pig farms than population controls. This shows that direct environmental spread from neighbouring pig farms of MRSA CC398 is unlikely. Instead, community spread through other means of transmission than direct spread from farms may more likely explain the clustering of MUO CC398 in livestock-dense areas.
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影响因子：
11.8
作者：
van Cleef BA;Monnet DL;Voss A;Krziwanek K;Allerberger F;Struelens M;Zemlickova H;Skov RL;Vuopio-Varkila J;Cuny C;Friedrich AW;Spiliopoulou I;Pászti J;Hardardottir H;Rossney A;Pan A;Pantosti A;Borg M;Grundmann H;Mueller-Premru M;Olsson-Liljequist B;Widmer A;Harbarth S;Schweiger A;Unal S;Kluytmans JA
通讯作者：
Kluytmans JA
影响因子：
4.5
作者：
Carrel, Margaret;Schweizer, Marin L.;Perencevich, Eli N.
通讯作者：
Perencevich, Eli N.
影响因子：
4.4
作者：
Friese, A.;Schulz, J.;Roesler, U.
通讯作者：
Roesler, U.
影响因子：
11.8
作者：
Lewis HC;Mølbak K;Reese C;Aarestrup FM;Selchau M;Sørum M;Skov RL
通讯作者：
Skov RL
在1999年至2011年，丹麦无牲畜接触的患者中，抗甲基肽的金黄色葡萄球菌CC398是疾病的越来越多的原因。
DOI：
10.2807/1560-7917.es.2015.20.37.30021
发表时间：
2015
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Larsen J;Petersen A;Sørum M;Stegger M;van Alphen L;Valentiner-Branth P;Knudsen LK;Larsen LS;Feingold B;Price LB;Andersen PS;Larsen AR;Skov RL
通讯作者：
Skov RL