Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale.

Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale.
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DOI:
10.1007/s10334-016-0561-4
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发表时间:
2016-06
期刊:
Magma (New York, N.Y.)
影响因子:
--
通讯作者:
Wald LL
Wald LL
中科院分区:
其他
文献类型:
--
作者:
Budinger TF;Bird MD;Frydman L;Long JR;Mareci TH;Rooney WD;Rosen B;Schenck JF;Schepkin VD;Sherry AD;Sodickson DK;Springer CS;Thulborn KR;Uğurbil K;Wald LL

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自2012年以来,一直在设计和制造14 T及以上至20 T的磁共振成像(MRI)和波谱(MRS)仪器。这项倡议得到了来自美国和欧洲的22名感兴趣的参与者的支持,其中15人是本综述的作者。高温超导体材料的进展、低温冷却工程的进展、非持久模式稳定磁体的前景以及从用于核聚变的大口径、高场磁体工程获得的经验支持在至少16 cm直径体积和68 cm口径尺寸上具有1 ppm均匀性的人脑MRI和MRS系统的可行性。十二神经科学的机会,以及生物物理和生理效应的分析,以调查之前,暴露于人类受试者的高领域的14 T及以上。
An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.
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